Advances in molecular signaling pathways related to endometrial adhesions treated by stem cells related molecular signaling pathways
MA Guohui1 HUANG Yanhong2▲
1.Department of Clinical Medicine of Chinese and Western Medicine, the First Clinical Medical College of Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Department of Reproductive Endocrinology, Xi’an International Medical Center Hospital, Shaanxi Province, Xi’an 710100, China
Abstract：Intrauterine adhesion (IUA) is an important cause of infertility due to endometrial injury and abnormal adhesion caused by infection, abortion and repeated intrauterine operations. At present, for the treatment of IUA, mild to moderate patients can still achieve a certain effect through traditional treatment, but for patients with severe or extensive endometrial injury, endometrial regeneration and functional recovery has become a clinical thorny problem. With the extensive research of stem cells, stem cells with low immunogenicity, proliferation and differentiation advantages are considered to be one of the most potential methods in the treatment of intrauterine adhesions. Previous studies have shown that the paracrine effect of stem cells can promote the formation of new blood vessels and improve intrauterine fibrosis by secreting growth factors and inhibiting inflammation in the lesion area. In this paper, we review the existing molecular mechanisms of stem cell therapy for intrauterine adhesions in order to provide guidance for future research.
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