百乐眠胶囊联合艾司西酞普兰片治疗失眠伴抑郁焦虑的临床效果

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摘要目的探讨百乐眠胶囊联合艾司西酞普兰片治疗失眠伴抑郁焦虑的临床效果。方法选取2016年2月～2018年4月河北大学附属医院收治的失眠伴抑郁焦虑患者143例。根据随机数字表法分为对照组（n = 71）和研究组（n = 72），对照组给予艾司西酞普兰片治疗，研究组则在对照组基础上联合百乐眠胶囊治疗。比较两组患者治疗2个月后临床效果，比较两组患者治疗前、治疗2个月后汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、匹兹堡睡眠质量指数（PSQI）、血清神经肽Y（NPY）、P物质（SP），记录两组患者治疗期间不良反应发生情况。结果研究组患者治疗后总有效率显著高于对照组（P ＜ 0.05）。两组患者治疗2个月后HAMA、HAMD及PSQI均较治疗前降低，且研究组低于对照组（P ＜ 0.05）。两组患者治疗2个月后血清NPY水平较治疗前升高，且研究组高于对照组（P ＜ 0.05），SP水平较治疗前降低，且研究组低于对照组（P ＜ 0.05）。研究组治疗期间不良反应总发生率低于对照组（P ＜ 0.05）。结论百乐眠胶囊联合艾司西酞普兰片治疗失眠伴抑郁焦虑，效果确切，可有效改善患者临床症状，改善患者血清NPY、SP水平，且能有效降低不良反应发生率。

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	张东子1 陈亚兰2 刘建丛3

关键词 ：百乐眠胶囊, 艾司西酞普兰片, 失眠伴抑郁焦虑, 临床研究

Abstract：Objective To investigate the clinical effect of Bailemian Capsules combined with Escitalopram Tablets in the treatment of insomnia with depression and anxiety. Methods From February 2016 to April 2018, 143 cases of insomnia patients with depression and anxiety admitted to the Affiliated Hospital of Hebei University were selected. According to the random number table method, they were divided into the control group (n = 71) and the research group (n = 72). The control group was treated with Escitalopram Tablets, while the research group was treated with Bailemian Capsules on the basis of the control group. The clinical effects of the two groups were compared after 2 months of treatment, compared two groups of patients Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD), Pittsburgh sleep quality index (PSQI), serum neuropeptide Y (NPY) and substance P (SP) were compared before and after 2 months treatment, adverse reactions during treatment were recorded in both groups. Results The total effective rate of the study group was significantly higher than that of the control group (P ＜ 0.05). HAMA, HAMD and PSQI of the two groups were decreased after 2 months of treatment compared with those before treatment, and the study group was lower than the control group (P ＜ 0.05). After 2 months of treatment, the serum NPY level in the two groups was higher than that before treatment, and the level of SP in the study group was lower than that in the control group (P ＜ 0.05). The total incidence of adverse reactions during treatment in the study group was lower than that in the control group (P ＜ 0.05). Conclusion Bailemian Capsules combined with Escitalopram Tablets for the treatment of insomnia with depression and anxiety has an accurate effect, which can effectively improve the clinical symptoms of patients, improve the serum NPY and SP levels of patients, and effectively reduce the incidence of adverse reactions.

Key words： Bailemian Capsules Escitalopram Tablets Insomnia with depression and anxiety Clinical study

基金资助:河北省医学科学研究重点课题计划项目（2014 0028）。

引用本文:

张东子1 陈亚兰2 刘建丛3. 百乐眠胶囊联合艾司西酞普兰片治疗失眠伴抑郁焦虑的临床效果[J]. 中国医药导报, 2019, 16(17): 133-136.
ZHANG Dongzi1 CHEN Yalan2 LIU Jiancong3. Clinical effect of Bailemian Capsules combined with Escitalopram Tablets in the treatment of insomnia with depression and anxiety. 中国医药导报, 2019, 16(17): 133-136.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I17/133

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