Clinical efficacy of Butylphthalide in combination with Alprostadil Injection in the treatment of posterior circulation ischemic vertigo
LIU Yafang1,2 HUANG Yongmei3▲ DAI Jun1 CAO Xiongbin1,2 SHI Yunqiong1
1.Department of Neurology, Huangshi Central Hospital of Edong Healthcare Group Affiliated Hospital of Hubei Polytechnic University, Hubei Province, Huangshi 435000, China;
2.Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Hubei Province, Huangshi 435000, China;
3.Huangshi Center for Disease Control and Prevention, Hubei Province, Huangshi 435000, China
Abstract:Objective To observe the curative efficacy of Butylphthalide in combination with Alprostadil Injection in patients with posterior circulation ischemic vertigo. Methods One hundred and ten patients with posterior circulation ischemic vertigo who received therapy in Huangshi Central Hospital of Edong Healthcare Group from January to October 2016 were collected as observational objects and randomly divided into the control group (55 cases) and the observation group (55 cases) according to random number table. Besides conventional treatment, the control group was treated with Alprostadil Injection, while the observation group was treated with Butylphthalide in combination with Alprostadil Injection. After treatment of 2 weeks, the curative efficacy, blood velocity of posterior circulation before and after treatment and adverse reactions were compared. Results Assessment of curative efficacy of vertigo showed that the total effective rate in the observation group was statistically higher than that in the control group (94.5% vs 81.8%, P < 0.05). Before treatment, there were no significant differences of blood velocity of basilar artery, left vertebral artery and right vertebral artery between the two groups (P > 0.05). After treatment, the indexes above in the two groups were all significantly faster than those before treatment (all P < 0.05), and blood velocity of basilar artery, left vertebral artery and right vertebral artery in the observation group was higher than those of control group (all P < 0.05). During the treatment, there was no case with severe adverse reactions, and the incidence of adverse reactions in the control group and the observation group had no statistically significant difference (5.4% vs 7.3%, P > 0.05). Conclusion Butylphthalide in combination with Alprostadil Injection is effective for patients with posterior circulation ischemic vertigo, which can improve the curative efficacy, speed up the blood velocity of posterior circulation, with low incidence of adverse reactions, it is worthy of clinical application.
刘雅芳1,2 黄咏梅3▲ 戴军1 曹雄彬1,2 石云琼1. 丁苯酞联合前列地尔注射液治疗后循环缺血性眩晕的临床效果[J]. 中国医药导报, 2017, 14(18): 145-148.
LIU Yafang1,2 HUANG Yongmei3▲ DAI Jun1 CAO Xiongbin1,2 SHI Yunqiong1. Clinical efficacy of Butylphthalide in combination with Alprostadil Injection in the treatment of posterior circulation ischemic vertigo. 中国医药导报, 2017, 14(18): 145-148.
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