Changes of plasma TSP-1 and PAF level in children with acute Kawasaki disease and their clinical significance
JIANG Yongmei1,2 CHEN Tingting3 ZHOU Kaiyu4 LAI Meimei5
1.West China Hospital of Sichuan University, Sichuan Province, Chengdu 610041, China;
2.Infectious Disease Department, Chengdu Women′s and Children′s Central Hospital, Sichuan Province, Chengdu 610017, China;
3.Department of Cardiology, Chengdu Women′s and Children′s Central Hospital, Sichuan Province, Chengdu 610017, China;
4.Department of Cardiology, West China Women′s and Children′s Hospital, Sichuan Province, Chengdu 610041, China;
5.Department of Laboratory, Chengdu Women′s and Children′s Central Hospital, Sichuan Province, Chengdu 610017, China
Abstract：Objective To study the changes and clinical significance of plasma platelet activating factor (PAF) and thrombospondin-1 (TSP-1) levels in children with acute Kawasaki disease (KD). Methods A total of 107 children with KD who were treated in West China Hospital of Sichuan University ("our hospital" for short) from January 2015 to January 2018 were selected as KD group. They were divided into coronary artery expansion group (n = 43) and non-coronary expansion group (n = 64) according to echocardiographic findings. Thirty cases of indirect inguinal hernia in our hospital in the same period were selected as control group. The levels of TSP-1, PAF and platelets（PLT） in the acute, subacute and recovery phases of the KD group and the control group were detected by enzyme-linked immunosorbent assay (ELISA). The differences among different indicators of each group were compared. Results The levels of plasma PAF, TSP-1 and PLT in KD group with the acute phase were significantly higher than those in control group (all P < 0.05). The plasma levels of PAF and TSP-1 in KD group increased in recovery, subacute and acute stages (all P < 0.05). The plasma PAF level in coronary artery injury group was significantly higher than that in non-coronary injury group (P < 0.05), but there was no significant difference in plasma PAF level between KD group in the subacute and recovery phases and non-coronary injury group (P > 0.05). There was no significant differences in TSP-1 level and PLT count between coronary artery injury group in the acute, subacute, and recovery phase and non-coronary injury group (P > 0.05). There was no correlation between plasma TSP-1 and PAF, PLT in KD group in the acute phase（r = 0.314, 0.051, P > 0.05）, but there was a significant positive correlation between PAF and PLT (r = 0.614, P < 0.05). Conclusion The plasma levels of PAF and TSP-1 are significantly increased in the acute phase of KD, and PAF is significantly increased in coronary artery injury. Both PAF and TSP-1 are involved in the occurrence and development of KD, and might be used as markers for early diagnosis of KD.
蒋永梅1,2 陈婷婷3 周开宇4 赖梅梅5. 急性期川崎病患儿血浆TSP-1、PAF水平变化及临床意义[J]. 中国医药导报, 2019, 16(19): 113-116.
JIANG Yongmei1,2 CHEN Tingting3 ZHOU Kaiyu4 LAI Meimei5. Changes of plasma TSP-1 and PAF level in children with acute Kawasaki disease and their clinical significance. 中国医药导报, 2019, 16(19): 113-116.
2019, Vol. 16 
京公网安备 11010502046598号