Analysis of influencing factors of carotid plaque in patients with type 2 diabetes mellitus
ZHANG Rui1 ZHAO Xiaoran1 GUO Hongying2 FANG Liang1 LIU Xiaoyan1
1.Department of Endocrine, Affiliated Hospital of Chengde Medical University, Hebei Province, Chengde 067000, China;
2.Department of Medical, Tianjin Medical University General Hospital Airport Hospital, Tianjin 300308, China
Abstract：Objective To investigate the risk factors of carotid plaque in patients with type 2 diabetes mellitus. Methods A total of 192 patients with type 2 diabetes mellitus who were admitted and hospitalized in Affiliated Hospital of Chengde Medical University from January 2016 to January 2018 were selected for the study. They were divided into plaque group (n = 101) and non-plaque group (n = 91) according to intima-media thickness (IMT). Clinical data and laboratory indicators were collected and compared between the two groups. Risk factors of carotid plaque were analyzed by binary multivariate Logistic analysis. Results The age, waist circumference, duration of diabetes mellitus, number of smokers, glycosylated hemoglobin (HbA1c), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) levels in plaque group were significantly higher than those in non-plaque group (P < 0.05), while 25-hydroxyvitamin D3 [25 (OH) D3] levels and the number of patients taking statins were significantly lower than those in non-plaque group (P < 0.05), the differences were statistically significant (P < 0.05). Multivariate Logistic analysis showed that the duration of diabetes mellitus (OR: 1.06, 95%CI: 1.03-1.08, P = 0.021), smoking (OR: 1.13, 95%CI: 1.10-1.16, P = 0.005), HbA1c (OR: 1.46, 95%CI: 1.24-1.54, P = 0.010) and LDL-C (OR: 1.28, 95%CI: 1.16-1.42, P = 0.014) were the risk factors for carotid artery plaque, and elevated level of 25(OH)D3（OR: 0.84，95%CI: 0.82-0.87, P = 0.000） and taking statins（OR: 0.78，95%CI: 0.72-0.82, P = 0.039）were the protective factors. Conclusion With the prolongation of the course of disease, the risk of carotid plaque in type 2 diabetes mellitus increased. Smoking, elevated levels of HBA1c and LDL-C all can increase the risk of carotid plaque, while high level of 25 (OH) D3 and taking statins may delay the development of carotid plaque.
2019, Vol. 16 
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