Clinical effect of self-made Wenwei Sanhan Decoction in the treatment of chronic atrophic gastritis with spleen-stomach deficiency and cold type
MA Runxing1 MA Yushou2
1.Department of Traditional Chinese Medicine, Qinghai Transportation Hospital, Qinghai Province, Xi′ning 810001, China;
2.Department of Traditional Chinese Medicine, the First People′s Hospital of Huangzhong County of Qinghai Province, Qinghai Province, Huangzhong 810000, China
Abstract：Objective To explore clinical effect of self-made Wenwei Sanhan Decoction in the treatment of chronic atrophic gastritis (CAG) with spleen-stomach deficiency and cold type. Methods One hundred and three CAG patients with spleen-stomach deficiency and cold type admitted to Qinghai Transportation Hospital from March 2016 to August 2018 were selected, they were divided into control group (n = 51) and study group (n = 52) according to the random number table method. Control group was treated with Qiwei Weitong Capsules and study group was treated with Wenwei Sanhan Decoction on the basis of control group. Clinical effect, clinical symptom score and thromboxane B2 (TXB2), pepsinogen (PG) were compared between two groups. Incidence of adverse reactions during the treatment in two groups was observed. Results After treatment of 8 weeks, total effective rate of study group was significantly higher than that of control group, there was a significant difference (P < 0.05). After treatment of 8 weeks, scores of clinical symptoms such as dry mouth and bitter mouth, fullness of upper abdomen, fatigue, poor appetite, dyspepsia in both groups were lower than those before treatment, and those in study group were lower than those in control group (P < 0.05). After treatment of 8 weeks, plasma TXB2 level of two groups was lower than that before treatment, and level of TXB2 in study group was lower than that in control group (P < 0.05). After treatment of 8 weeks, level of plasma PGⅠ in two groups was higher than that before treatment, and that in study group was higher than that in control group (P < 0.05). There was no significant difference in plasma PGⅡ level between two groups before treatment and after treatment of 8 weeks (P > 0.05). There was no significant difference in incidence rate of adverse reaction between two groups during treatment (P > 0.05). Conclusion Self-made Wenwei Sanhan Decoction is effective in the treatment of CAG with spleen-stomach deficiency and cold type. It can effectively improve clinical symptoms of patients and the levels of TXB2 and PG in serum without increasing the incidence rate of adverse reaction. It has high clinical value.
马润兴1 马玉寿2. 自拟温胃散寒汤治疗脾胃虚寒型慢性萎缩性胃炎的临床效果[J]. 中国医药导报, 2019, 16(25): 118-121.
MA Runxing1 MA Yushou2. Clinical effect of self-made Wenwei Sanhan Decoction in the treatment of chronic atrophic gastritis with spleen-stomach deficiency and cold type. 中国医药导报, 2019, 16(25): 118-121.
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2019, Vol. 16 
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