脑血流自动调节在脑血管疾病中的研究进展

摘要
图/表
参考文献(37)
相关文章 (6)

全文: PDF (600 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要脑血管疾病是神经科最常见疾病之一，同时也是导致患者死亡和残疾的主要原因。脑血管血流动力学改变在脑血管疾病发生和发展中起着重要作用，脑血流自动调节（CA）是大脑不受外周血压的影响根据代谢需要维持脑血流量相对恒定的能力。近年来，越来越多的研究显示：脑血管疾病发生时，CA机能会受到不同程度的损伤，继而增加患者脑血管意外事件的复发风险。本文通过文献回顾，围绕CA机制、CA与脑血管疾病之间的关系、CA及其临床应用等多个方面展开综述，旨在为脑血管疾病研究、临床应用提供新的思路和方向。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	沈艳霞周艳霞胡诗雨池枫江诗睿杨巧玲任力杰

关键词 ：脑血流自动调节, 脑血管疾病, 缺血性卒中, 出血性卒中

Abstract：Cerebrovascular disease is one of the most common diseases in neurology department, and it is also the leading cause of death and disability. Cerebrovascular hemodynamic changes play an important role in the occurrence and development of cerebrovascular diseases. Cerebral autoregulation (CA) is the ability of cerebral arterioles to maintain the relative constancy of cerebral blood flow in accordance with brain′s metabolic needs, regardless of changes in blood pressure. In recent years, more and more studies have shown that CA is impaired in cerebrovascular disease to some extent, which in turn increases the risk of cerebrovascular recurrence. This article gives review of CA mechanism, the relationship between CA and cerebrovascular disease, CA and clinical application through literature review, aiming to provide new ideas and directions for the research and clinical application of CA in cerebrovascular diseases.

Key words： Cerebral autoregulation Cerebrovascular diseases Ischemic stroke Hemorrhagic stroke

基金资助:广东省深圳市卫生计生系统科研项目（SZLY2017012）。

通讯作者: 任力杰（1972-），男，博士，主任医师，硕士研究生导师；研究方向：缺血性卒中。

引用本文:

沈艳霞周艳霞胡诗雨池枫江诗睿杨巧玲任力杰. 脑血流自动调节在脑血管疾病中的研究进展[J]. 中国医药导报, 2019, 16(34): 65-68.
SHEN Yanxia ZHOU Yanxia HU Shiyu CHI Feng JIANG Shirui YANG Qiaoling REN Lijie. Research progress of cerebral autoregulation in cerebrovascular diseases. 中国医药导报, 2019, 16(34): 65-68.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I34/65

[1] Aaslid R，Lindegaard KF，Sorteberg W，et al. Cerebral autoregulation dynamics in humans [J]. Stroke，1989，20（1）：45-52.
[2] de Jong DLK，Tarumi T，Liu J，et al. Lack of linear correlation between dynamic and steady-state cerebral autoregulation [J]. J Physiol，2017，595（16）：5623-5636.
[3] Hamner JW，Tan CO，Lee K，et al. Sympathetic Control of the Cerebral Vasculature in Humans [J]. J Physiol，2010， 590（24）：6343-6352.
[4] Hamner JW，Tan CO，Tzeng YC，et al. Holinergic control of the cerebral vasculature in humans [J]. J Physiol，2012， 590（24）：6343-6352.
[5] Schmetterer L，Findl O，Strenn K，et al. Role of NO in the O2 and CO2 responsiveness of cerebral and ocular circulation in humans [J]. Am J Physiol，1997，273（2）：2005-2012.
[6] Hoiland RL，Smith KJ，Carter HH，et al. Shear-mediated dilation of the internal carotid artery occurs independent of hypercapnia [J]. Am J Physiol Heart Circ Physiol，2017， 313（1）：H24.
[7] Sasaki H，Hirasawa A，Washio T，et al. Acute effect of coffee drinking on dynamic cerebral autoregulation [J]. Eur J Appl Physiol，2016，116（5）：879-884.
[8] Guo ZN，Xing Y，Wang S，et al. Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease：Diffuse and sustained [J]. Sci Rep，2015，5：15269.
[9] Xiong L，Tian G，Lin WH，et al. Is Dynamic Cerebral Autoregulation Bilaterally Impaired after Unilateral Acute Ischemic Stroke? [J]. J Stroke Cerebrovasc，2017，26（5）：1081-1087.
[10] Llwyd O，Salinet ASM，Panerai RB，et al. Cerebral Haemodynamics following Acute Ischaemic Stroke：Effects of Stroke Severity and Stroke Subtype [J]. Cerebrovasc Dis，2018，8（2）：80-89.
[11] Petersen NH，Ortega-Gutierrez S，Reccius A，et al. Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke [J]. Cerebrovasc Dis，2015，39（2）：144-150.
[12] Xiong L，Lin WH，Han JH，et al. Enhancing cerebral perfusion with external counterpulsation after ischaemic stroke：how long does it last? [J]. J Neurol Neuosur Ps，2016，87（5）：531-536.
[13] Castro P，Serrador JM，Rocha I，et al. Efficacy of Cerebral Autoreguiation in Early Ischemic Stroke Predicts Smaller Infarcts and Better Outcome [J]. Front Neurol，2017，8：113.
[14] Castro P，Azevedo E，Serrador J，et al. Hemorrhagic transformation and cerebral edema in acute ischemic stroke：Link to cerebral autoregulation [J]. J Neurol Sci，2017， 372：256-261.
[15] Castro P，Azevedo E，Rocha I，et al. Chronic kidney disease and poor outcomes in ischemic stroke：is impaired cerebral autoregulation the missing link? [J]. Bmc Neurol，2018，18（1）：21.
[16] Kuo HK，Lipsitz LA. Cerebral white matter changes and geriatric syndromes：is there a link? [J]. J Gerontol，2004， 59（8）：M818-M826.
[17] Austin SA，Santhanam AV，Katusic ZS. Endothelial nitric oxide modulates expression and processing of amyloid precursor protein [J]. Circ Res，2010，107（12）：1498-1502.
[18] Brickman AM，Guzman VA，Gonzalez-Castellon M，et al. Cerebral autoregulation，beta amyloid，and white matter hyperintensities are interrelated [J]. Neurosci Lett，2015， 592：54-58.
[19] Oeinck M，Neunhoeffer F，Buttler KJ，et al. Dynamic cerebral autoregulation in acute intracerebral hemorrhage [J]. Stroke，2013，44（10）：2722-2728.
[20] Ma HY，Guo ZN，Liu J，et al. Temporal Course of Dynamic Cerebral Autoregulation in Patients With Intracerebral Hemorrhage [J]. Stroke，2016，47（3）：674-681.
[21] Qureshi AI，Suri MFK，Abu N，et al. Trends in hospitalization and mortality for subarachnoid hemorrhage and unruptured aneurysms in the United States [J]. Neurosurgery，2005，57（1）：1-8.
[22] Gijn JV，Kerr RS，Rinkel GJ. Subarachnoid haemorrhage [J]. Lancet. 2001，357（9259）：886-886.
[23] De Rooij NK，Rinkel GJE，Dankbaar JW，et al. Delayed Cerebral Ischemia After Subarachnoid Hemorrhage：A Systematic Review of Clinical，Laboratory，and Radiological Predictors [J]. Stroke，2013，44（1）：43-54.
[24] Kassell NF，Sasaki T，Colohan AR，et al. Cerebral vasospasm following aneurysmal subarachnoid hemorrhage [J]. Stroke，1985，16（4）：562-572.
[25] Budohoski KP，Marek C，Peter S，et al. Impairment of cerebral autoregulation predicts delayed cerebral ischemia after subarachnoid hemorrhage：a prospective observational study [J]. Stroke，2012，43（12）：3230.
[26] Lam JM，Smielewski P，Czosnyka M，et al. Predicting delayed ischemic deficits after aneurysmal subarachnoid hemorrhage using a transient hyperemic response test of cerebral autoregulation [J]. Neurosurgery，2000，47（4）：819-825.
[27] Santos GA，Petersen N，Zamani AA，et al. Pathophysiologic differences in cerebral autoregulation after subarachnoid hemorrhage [J]. Neurology，2016，86（21）：1950-1956.
[28] Kirkpatrick PJ，Turner CL，Smith C，et al. Simvastatin in aneurysmal subarachnoid haemorrhage（STASH）：a multicentre randomised phase 3 trial [J]. Lancet Neurol，2014， 13（7）：666-675.
[29] Semenyutin VB，Asaturyan GA，Nikiforova AA，et al. Predictive Value of Dynamic Cerebral Autoregulation Assessment in Surgical Management of Patients with High-Grade Carotid Artery Stenosis [J]. Front Physiol，2017，8：872.
[30] Reinhard M，Roth M，Muller T，et al. Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation [J]. Stroke，2004，35（6）：1381-1387.
[31] Su HL，Huo CC，Wang BT，et al. Alterations in the coupling functions between cerebral oxyhaemoglobin and arterial blood pressure signals in post-stroke subjects [J]. Plos One，2018，13（4）：e0195936.
[32] Parthasarathy AB，Gannon KP，Baker WB，et al. Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy [J]. J Cerebr Blood F Met，2018，38（2）：230-240.
[33] Nogueira RC，Saeed NP，Bor-Seng-Shu E，et al. The carotid artery as an alternative site for dynamic autoregulation measurement：an inter-observer reproducibility study [J]. Med Eng Phys，2016，38（7）：690-694.
[34] Chi NF，Ku HL，Wang CY，et al. Dynamic Cerebral Autoregulation Assessment Using Extracranial Internal Car-otid Artery Doppler Ultrasonography [J]. Ultrasound Med Biol，2017，43（7）：1307-1313.
[35] Lee YK，Tang SC，Jeng JS，et al. Nonlinear analyses applied in cerebral autoregulation and blood flow changes in patients with acute intracerebral hemorrhage [J]. Biomed Signal Proces，2017，31：102-107.
[36] Panerai RB，Jara JL，Saeed NP，et al. Dynamic cerebral autoregulation following acute ischaemic stroke：Comparison of transcranial Doppler and magnetic resonance imaging techniques [J]. J Cereb Blood F Met，2016，36（12）：2194-2202.
[37] Chi NF，Wang CY，Chan L，et al. Comparing Different Recording Lengths of Dynamic Cerebral Autoregulation：5 versus 10 Minutes [J]. Biomed Res Int，2018，2018：1-6.