Relationship between serum HMGB1 and sTLT-1 levels and adverse cardiovascular events after percutaneous coronary intervention in patients with acute myocardial infarction
LIANG Chunfang1 CHEN Zihui2 DONG Yanzhang1
1.Department of Emergency, the Fourth People′s Hospital of Langfang City of Hebei Province, Hebei Province, Langfang 065700, China;
2.Department of General Surgery, the Fourth People′s Hospital of Langfang City of Hebei Province, Hebei Province, Langfang 065700, China
Abstract：Objective To investigate the relationship between serum high-mobility group box-1 (HMGB1) and soluble triggering receptor expressed on myeloid cells-like transcript-1 (sTLT-1) levels and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods From March 2016 to March 2018, 198 cases with AMI patients after PCI admitted to the Fourth People′s Hospital of Langfang City of Hebei Province were selected. According to the whether or not MACE happens, they were divided into MACE group (n = 57) and non-MACE group (n = 141). The control group included 50 patients who had no history of AMI and acute or chronic infection. Heart rate (HR), Killip cardiac function grading, operation time, serum levels of cholesterol, glycosylated hemoglobin (HbA1c), HMGB1, sTLT-1, high-sensitivity C-reactive protein (hs-CRP) and cardiac troponin I (cTnI) were compared among the three groups. Risk factors of MACE after PCI in AMI patients and correlation analysis between HMGB1, sTLT-1 levels and hs-CRP, cTnI levels were analyzed. ROC curve was used to evaluate the predictive value of serum HMGB1 and sTLT-1 for the occurrence of MACE after operation. Results There were no statistical significance differences in HR, Killip cardiac function grading, operation time, HbA1c and cholesterol among the three groups (all P > 0.05). The levels of HMGB1, sTLT-1, hs-CRP and cTnI in MACE group and non-MACE group were higher than those in control group, the levels of HMGB1, sTLT-1, hs-CRP and cTnI in MACE group were higher than those in non-MACE group, and the differences were statistically significant (all P < 0.05). Logistic regression analysis showed that HMGB1 sTLT-1, hs-CRP and cTnI levels were independent risk factors for MACE after PCI in AMI patients. After PCI, serum HMGB1 levels in AMI patients were positively correlated with hs-CRP and cTnI levels (r = 0.422, 0.491, P < 0.05), and sTLT-1 levels were positively correlated with hs-CRP and cTnI levels (r = 0.404, 0.520, P < 0.05). When the diagnostic threshold of HMGB1 were 79.75 μg/L, the sensitivity and specificity of HMGB1 were 0.719 and 0.759. When the diagnostic threshold of sTLT-1 was 595.72 pg/mL, the sensitivity was 0.544 and the specificity was 0.794. The sensitivity and specificity of the two indexes were 0.842 and 0.858. Conclusion Elevated serum HMGB1 and sTLT-1 levels in AMI patients after PCI are also risk factors for the occurrence of MACE in the near future after PCI. Early combined detection can effectively predict the occurrence of MACE in AMI patients after PCI.
2020, Vol. 17 
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