糖尿病足溃疡基础及辅助治疗的研究进展

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摘要糖尿病足溃疡（DFU）是糖尿病患者致残率最高的晚期并发症之一。治疗过程中存在耗时长、显效慢、易复发等难题。目前临床治疗DFU的方法很多，除去原发病的处理，大体可分基础治疗和辅助治疗两部分。基础治疗包括彻底清创、卸载创面压力、控制感染等；辅助治疗包括氧气疗法、负压疗法、重组人生长因子、能量疗法等。近年来，采用联合方案治疗DFU的临床报道越来越多，其或将为DFU治疗方式的研发提供新的方向。本文就DFU的基础及辅助治疗研究进展做一简要综述，以期为临床医生在选择DFU的联合治疗方案时提供思路与帮助。

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	宋爱波1 孙劲2

关键词 ：糖尿病足溃疡, 基础治疗, 辅助治疗, 研究进展

Abstract：Diabetic foot ulcer (DFU) is one of the the most disabling late complications in diabetic patients, which has many problems during treatment such as time-consuming, slow effect, easy to relapse, etc. Currently, there are various treatment methods for DFU, which can be divided into basic treatment and adjuvant treatment except the treatment of primary disease. The basic treatment includes thorough debridement, unloading of wound pressure and infection control. The adjuvant therapy includes oxygen therapy, negative pressure therapy, recombinant human growth factor, energy therapy, etc. In recent years, there have been more and more clinical reports on the use of combination regimens for DFU treatment, which may provide a new direction for the development of DFU treatment. This paper briefly reviews the research progress of DFU in terms of its foundation and adjuvant therapy, so as to provide clinicians with ideas and help in choosing DFU combined therapy.

Key words： Diabetic foot ulcer Basic therapy Adjuvant therapy Research progress

基金资助:湖北省卫生健康科研基金资助项目（WJ2019H5 68）。

通讯作者: 孙劲（1977-），男，硕士，主任医师，硕士生导师；研究方向：创伤与创面修复。

作者简介: 宋爱波（1991-），男，三峡大学医学院2017级外科学专业在读硕士研究生；研究方向：创面修复。

引用本文:

宋爱波1 孙劲2. 糖尿病足溃疡基础及辅助治疗的研究进展[J]. 中国医药导报, 2020, 17(13): 66-68,72.
SONG Aibo1 SUN Jin2. Research progress on basic and adjuvant therapy of diabetic foot ulcer. 中国医药导报, 2020, 17(13): 66-68,72.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2020/V17/I13/66

[1] Leila Y，Hajieh S，Iraj N，et al. Incidence and Risk Factors of Diabetic Foot Ulcer：A Population-Based Diabetic Foot Cohort（ADFC Study）-Two-Year Follow-Up Study [J]. Int J Endocrinol，2018，2018：7631659.
[2] Hicks CW，Selvarajah S，Mathioudakis N，et al. Burden of Infected Diabetic Foot Ulcers on Hospital Admissions and Costs [J]. Ann Vasc Surg，2016，33：149-158.
[3] Xu Z，Ran X. Diabetic foot care in China：challenges and strategy [J]. Lancet Diabetes Endocrinol，2016，4（4）：297-298.
[4] Lavery LA，Davis KE，Berriman SJ，et al. WHS guidelines update：Diabetic foot ulcer treatment guidelines [J]. Wound Repair Regen，2016，24（1）：112-126.
[5] Everett E，Mathioudakis N. Update on management of diabetic foot ulcers [J]. Ann N Y Acad Sci，2018，1411（1）：153-165.
[6] Hingorani A，LaMuraglia GM，Henke P，et al. The management of diabetic foot：A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine [J]. J Vasc Surg，2016，63（2 Suppl）：3S-21S.
[7] Michailidis L，Bergin SM，Haines TP，et al. A Systematic Review to Compare the Effect of Low-frequency Ultrasonic Versus Nonsurgical Sharp Debridement on the Healing Rate of Chronic Diabetes-related Foot Ulcers [J]. Ostomy Wound Manage，2018，64（9）：39-46.
[8] Yavuz M，Ersen A，Hartos J，et al. Plantar shear stress in individuals with a history of diabetic foot ulcer：An emerging predictive marker for foot ulceration [J]. Diabetes Care，2017，40（2）：e14-e15.
[9] Bus SA，Armstrong DG，Van Deursen RW，et al. IWGDF guidance on footwear and offloading interventions to prevent and heal foot ulcers in patients with diabetes [J]. Diabetes Metab Res Rev，2016 Suppl 1，32：25-36.
[10] Bus SA. The Role of Pressure Offloading on Diabetic Foot Ulcer Healing and Prevention of Recurrence [J]. Plast Reconstr Surg，2016，138（3 Suppl）：179S-187S.
[11] Bus SA，Van Netten JJ，Lavery LA，et al. IWGDF guidance on the prevention of foot ulcers in at-risk patients with diabetes [J]. Diabetes Metab Res Rev，2016，32 Suppl 1：16-24.
[12] Acar E，Kacιra BK. Predictors of Lower Extremity Amputation and Reamputation in the Diabetic Foot [J]. J Foot Ankle Surg，2017，56（6）：1218-1222.
[13] Abbas M，Uckay I，Lipsky BA. In diabetic foot infections antibiotics are to treat infection，not to heal wounds [J]. Expert Opin Pharmacother，2015，16（6）：821-832.
[14] Tae KT，Armstrong DG. Microbiology and Antimicrobial Therapy for Diabetic Foot Infections [J]. Infect Chemother，2018，50（1）：11-20.
[15] Markakis K，Faris AR，Sharaf H，et al. Local Antibiotic Delivery Systems：Current and Future Applications for Diabetic Foot Infections [J]. Int J Low Extrem Wounds，2018，17（1）：14-21.
[16] De Smet GHJ，Kroese LF，Menon AG，et al. Oxygen therapies and their effects on wound healing [J]. Wound Repair Regen，2017，25（4）：591-608.
[17] Driver VR，Reyzelman A，Kawalec J，et al. A Prospective，Randomized，Blinded，Controlled Trial Comparing Transdermal Continuous Oxygen Delivery to Moist Wound Therapy for the Treatment of Diabetic Foot Ulcers [J]. Ostomy wound Manag，2017，63（4）：12-28.
[18] Perren S，Gatt A，Papanas N，et al. Hyperbaric Oxygen Therapy in Ischaemic Foot Ulcers in Type 2 Diabetes：A Clinical Trial [J]. Open Cardiovasc Med J，2018，12：80-85.
[19] Chen W，Liang X，Nong Z，et al. The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy [J]. Med Chem，2019，15（5）：459-471.
[20] Jaffe L，Wu SC. Dressings，Topical Therapy，and Negative Pressure Wound Therapy [J]. Clin Podiatr Med Surg，2019，36（3）：397-411.
[21] 常宇，韩睿.负压封闭引流术治疗糖尿病足的研究进展[J].中国医药导报，2018，15（36）：32-35，43.
[22] 李军，张莉莉，张凤新，等.重组人酸性成纤维细胞生长因子促进慢性溃疡性创面愈合的临床研究[J].中国医药导报，2014，11（31）：49-51，60.
[23] Jhamb S，Vangaveti VN，Malabu UH. Genetic and molecular basis of diabetic foot ulcers：Clinical review [J]. J Tissue Viability，2016，25（4）：229-236.
[24] Ojalvo AG，Acosta JB，Marí YM，et al. Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction [J]. Int Wound J，2017，14（1）：214-225.
[25] Sridharan K，Sivaramakrishnan G. Growth factors for diabetic foot ulcers：Mixed treatment comparison analysis of randomized clinical trials：Growth factors for diabetic foot ulcers [J]. Br J Clin Pharmacol，2018，84（3）：434-444.
[26] Piaggesi A，Sambataro M，Nicoletti C，et al. Safety and effectiveness of therapeutic magnetic resonance in diabetic foot ulcers：a prospective randomised controlled trial [J]. J Wound Care，2016，25（12）：704-711.
[27] 王军辉，王利君，卞学平，等.不同物理因子治疗糖尿病足研究进展[J].中国医药导报，2010，7（2）：13-14.
[28] Brocco E，Ninkovic S，Marin M，et al. Diabetic foot management：multidisciplinary approach for advanced lesion rescue [J]. J Cardiovasc Surg（Torino），2018，59（5）：670-684.
[29] Kasiya MM，Mang′anda GD，Heyes S，et al. The challenge of diabetic foot care：Review of the literature and experience at Queen Elizabeth Central Hospital in Blantyre，Malawi [J]. Malawi Med J，2017，29（2）：218-223.