Clinical study of mild hypothermia combined with cerebroprotein hydrolysate in the treatment of neonatal asphyxia brain injury and its influence on blood GFAP
MU Yanshun LIU Weijuan GAO Jialing LIU Hongwei FAN Qingman
Department of Pediatrics, Huabei Petroleum Administration Bureau General Hospital, Hebei Province, Renqiu 062552, China
Abstract：Objective To observe the effect of mild hypothermia combined with cerebroprotein hydrolysate in the treatment of neonatal asphyxia brain injury and its influence on blood glial fibrillary acidic protein (GFAP). Methods Retrospective analysis was performed on 81 cases of neonatal asphyxia with moderate and severe brain injury admitted to Department of Neonatology, Huabei Petroleum Administration Bureau General Hospital from May 2018 to May 2020. According to the drug use, they were divided into cerebroprotein hydrolysate group (40 cases) and mild hypothermia combined with cerebroprotein hydrolysate group (41 cases). Two groups were given symptomatic support treatment, such as maintaining electrolyte balance, reducing intracranial pressure, anti infection, intravenous nutrition support, etc. Cerebroprotein hydrolysate group was treated with Trixerutin Brain Protein Hydrolysate Injection and mild hypothermia combined with cerebroprotein hydrolysate group was combined with head mild hypothermia treatment on the basis of cerebroprotein hydrolysate group. The consciousness recovery time, muscle tension recovery time, primary reflex recovery time and blood GFAP level were compared between two groups. Results The consciousness recovery time, muscle tension recovery time, primary reflex recovery time in mild hypothermia combined with cerebroprotein hydrolysate group were shorter than those in cerebroprotein hydrolysate group (all P < 0.05). Before treatment, there was no significant difference in blood GFAP level between the two groups (P ＞ 0.05). After seven days of treatment, the blood GFAP level in both groups were higher than those before treatment and after three days of treatment. After three days of treatment, the blood GFAP level in both groups were higher than those before treatment (all P < 0.05). After three, seven days of treatment, the blood GFAP level of the mild hypothermia combined with cerebroprotein hydrolysate group were lower than those of cerebroprotein hydrolysate group (all P < 0.05). Conclusion Mild hypothermia combined with cerebroprotein hydrolysate can significantly improve the clinical manifestations of neonatal asphyxia brain injury and the detection of blood GFAP is helpful for the prognosis of neonatal asphyxia brain injury.
穆艳顺 刘伟娟 高嘉陵 刘红伟 樊青曼. 亚低温联合脑蛋白水解物治疗新生儿窒息脑损伤的临床研究及对血GFAP的影响[J]. 中国医药导报, 2021, 18(6): 119-122.
MU Yanshun LIU Weijuan GAO Jialing LIU Hongwei FAN Qingman. Clinical study of mild hypothermia combined with cerebroprotein hydrolysate in the treatment of neonatal asphyxia brain injury and its influence on blood GFAP. 中国医药导报, 2021, 18(6): 119-122.
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2021, Vol. 18 
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