Effect of Simo Decoction combined with blue light irradiation in the treatment of neonatal jaundice and its influence on immune function
LI Xiaojing1 GONG Yajie1▲ CHU Wangyan1 DING Wei2
1.Ward One, Department of Pediatrics, Taihe Hospital of Traditional Chinese Medicine, Anhui Province, Taihe 236600, China;
2.Department of Pediatrics, the First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province, Hefei 230031, China
Abstract：Objective To explore the effect of Simo Decoction combined with blue light irradiation in the treatment of neonatal jaundice and its influence on immune function. Methods From January 2017 to January 2020, 100 newborns with pathological jaundice in Taihe Hospital of Traditional Chinese Medicine of Anhui Province were divided into control group of 50 cases and study group of 50 cases according to random number table method. Control group was treated with blue light irradiation, and study group was treated with Simo Decoction on the basis of control group. Both groups were treated for five days. Clinical efficacy, jaundice index level, jaundice regression time, serum transferrin (TRF), C-reactive protein (CRP) and peripheral blood CD4+, CD8+, CD4+/CD8+ levels were compared between two groups. The incidence of adverse reactions was observed in two groups. Results Total effective rate of study group was higher than that of control group, the difference was statistically significant (P < 0.05). After treatment, the jaundice index levels of two groups were lower than those before treatment, and study group was lower than that control group, the differences were statistically significant (P < 0.05). The jaundice regression time of study group was shorter than that of control group, and the difference was statistically significant (P < 0.05). After treatment, serum TRF level of two groups was higher than that before treatment, CRP level was lower than that before treatment, and serum TRF level of study group was higher than that of control group, CRP level of study group was lower than that of control group, the differences were statistically significant (P < 0.05). After treatment, CD4+, CD4+/CD8+ in two groups were higher than those before treatment, and study group was higher than that control group, the differences were statistically significant (P < 0.05). During the treatment, no serious adverse reactions occurred in two groups. Conclusion Clinical effect of Simo Decoction combined with blue light irradiation in the treatment of neonatal jaundice is significant, which can significantly promote jaundice regression, improve the immune function of the body, and has good safety.
李晓静1 宫雅杰1▲ 储王燕1 丁伟2. 四磨汤联合蓝光照射治疗新生儿黄疸的效果及对免疫功能的影响[J]. 中国医药导报, 2021, 18(11): 96-99，104.
LI Xiaojing1 GONG Yajie1▲ CHU Wangyan1 DING Wei2. Effect of Simo Decoction combined with blue light irradiation in the treatment of neonatal jaundice and its influence on immune function. 中国医药导报, 2021, 18(11): 96-99，104.
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