Research progress of spinal cord injury related signaling pathways in the repair of spinal cord injury
JING Cong1 WANG Zhigang1 WANG Jun1 DING Xiangqian1 ZOU Yanghong1 YU Hualin2▲ GENG Xin2▲
1.Graduate School, Kunming Medical University, Yunnan Province, Kunming 650500, China;
2.the Second Department of Neurosurgery, the First Affiliated Hospital of Kunming Medical University, Yunnan Province, Kunming 650500, China
Abstract：Spinal cord injury (SCI) is very common in clinical work, and its incidence has been increasing year by year in recent years. Due to the non-renderability of neurons after injury, the effect of active treatment for SCI patients is still very limited even through various means. This causes physical, psychological and emotional harm, as well as a significant economic burden on the family and society. With the in-depth study of various signaling pathways, it has been found that they all play an important regulatory role in the process of nerve injury and repair, especially play an important role in the proliferation, differentiation and metabolism of neural stem cells. This provides a new direction for SCI repair. Among them, the molecular mechanisms of Wnt, Notch, TGF-β/Smads and mTOR signaling pathways in SCI and the repair process are currently the focus of research. In this paper, the research achievements and progress of SCI related signaling pathways in SCI repair process are reviewed.
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