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| Advances in the role of cytokines secreted by tumor-associated macrophages in tumor microenvironment |
| LIU Luyao LIU Keke ZHANG Wenwen CAO Juan DU Aobo LI Bo |
| Experimental Teaching Center, Hospital of Stomatology, Jilin University, Jilin Province, Changchun 130021, China |
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Abstract Tumor microenvironment (TME) contains multiple cells and cytokines, which play an important role in tumor proliferation, invasion and metastasis. Tumor-associated macrophages (TAMs), as an important component of TME, mainly interact with tumor cells through the cytokines secreted by them to further regulate tumor progression. In this paper, the role of cytokines secreted by TAMs in TME was summarized, including tumor invasion, migration and angiogenesis. Targeting TAMs secreted cytokines in TME for intervention is expected to be a new therapeutic strategy for tumors.
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