Significance of macroprolactin detection in the female inpatients with schizophrenia
CHEN Haizhi1 FEI Xiaocong1 WANG Zhenhua1 SHEN Ye2 LEI Lilei1 ZHAO Xudong1 ZENG Lei1 REN Lihua1
1.Department of Psychiatry, the Third People′s Hospital of Huzhou City, Zhejiang Province, Huzhou 313000, China;
2.Clinical Laboratory, the Third People′s Hospital of Huzhou City, Zhejiang Province, Huzhou 313000, China
Abstract：Objective To explore the significance of macroprolactin (MPRL) detection in the female inpatients with schizophrenia. Methods From January 2018 to June 2019, 65 schizophrenics patients were collected in Department of Psychiatry, the Third People′s Hospital of Huzhou City, Zhejiang Province and all of them were treated with Risperidone Tablets. The menstrual situation of the patients was recorded during the treatment, and the contents of prolactin (PRL) and MPRL were measured by luminescent immunoassay and enzyme-linked immunosorbent assay respectively before and at the end of the sixth weekend of the treatment. The content of PRL and MPRL were compared by self-control study before and after the treatment, at the same time, according to the content of PRL and MPRL at the end of the sixth weekend, 65 patients were divided into the normal PRL group (16 cases) and the hyperprolactinemia group (49 cases). The hyperprolactinemia group was then divided into the macroprolactinemia group (21 cases) and the non-macroprolactinemia group (28 cases), and the menstrual delay in different groups was compared. Results The levels of PRL and MPRL in 65 patients after treatment were significantly increased compared with those before treatment, and the differences were highly statistically significant (all P ＜ 0.01). The number and incidence of menstrual delay of the normal PRL group , the hyperprolactinemia group, the macroprolactinemia group and the non-macroprolactinemia group were 2 cases (12.5%), 30 cases (61.2%), 5 cases (23.8%) and 25 cases (89.3%), respectively. The incidence of menstrual delay in four groups was compared in pairs, there was no significant difference between the macroprolactinemia group and the normal PRL group (P ＞ 0.05), the incidence of menstrual delay in the non-macroprolactinemia group was higher than that in the hyperprolactinemia group, the macroprolactinemia group and the normal PRL group, with highly statistically significant differences (all P ＜ 0.01). The incidence of menstrual delay in the hyperprolactinemia group was higher than that in the macroprolactinemia group and normal PRL group, with highly statistically significant differences (all P ＜ 0.01). Conclusion Macroprolactinemia caused by Risperidone may not lead to menstrual delay. The clinical detection of macroprolactin is helpful to guide the treatment of hyperprolactinemia.
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2020, Vol. 17 
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