Prognostic value of peripheral blood ALC / AMC combined with AGR in patients undergoing radical gastrectomy for gastric cancer
WANG Hui1 MA Boheng1▲ XU Fangzheng2
1.Department of Gastrointestinal Surgery, Rugao Hospital Affiliated to Nantong University, Jiangsu Province, Rugao 226500, China;
2.Department of General Surgery, Rugao Hospital Affiliated to Nantong University, Jiangsu Province, Rugao 226500, China
Abstract：Objective To investigate the prognostic value of peripheral blood absolute lymphocyte count (ALC)/absolute monocyte count (AMC) combined with serum albumin globulin ratio (AGR) in patients undergoing radical gastrectomy for gastric cancer. Methods A total of 96 patients who planned to undergo radical gastrectomy in Rugao Hospital Affiliated to Nantong University from January 2018 to January 2020 were selected. The patients who underwent radical gastrectomy were divided into recurrence group and non-recurrence group according to their prognosis. The clinicopathological features including TNM stage, differentiation degree, and lymph node metastasis were compared between the two groups. Logistic regression analysis was used to explore the influencing factors of postoperative recurrence, and receiver operator characteristic curve was used to evaluate the predictive value of peripheral blood ALC/AMC and AGR levels on postoperative recurrence. Results The proportion of undifferentiated/poorly differentiated, TNM stage Ⅲ, lymph node metastasis, peripheral blood ALC/AMC, and AGR levels in the recurrence group were higher than those in the non-recurrence group (P < 0.05). Stage Ⅲ, undifferentiated/poorly differentiated, lymph node metastasis, ALC/AMC, and AGR levels were risk factors for recurrence after radical gastrectomy (OR = 2.768, 3.040, 3.083, 4.976, 4.235, P < 0.05). The area under the curve of ALC/AMC and AGR combined in predicting postoperative recurrence was higher than that of ALC/AMC and AGR alone (P < 0.05). Conclusion The stage, undifferentiated/poorly differentiated, having lymph node metastasis, ALC/AMC, and AGR levels were all risk factors affecting the relapse group. ALC/AMC and AGR can affect the prognosis of patients, and the combination of the two can be used as a reference index to predict the recurrence after radical gastrectomy.
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