Correlation between the degree of coronary artery disease and Apo AI/Apo B, homocysteine and blood lipids
LI Lin1 SONG Tingting2▲
1.Second Department of Cardiology, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110033, China; 2.First Department of Cardiology, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110033, China
Abstract：Objective To investigate and analyze the correlation between the severity of coronary artery disease and apolipoprotein AI/apolipoprotein B (Apo AI/Apo B), homocysteine and blood lipids. Methods From December 2016 to December 2018, 67 patients with coronary heart disease diagnosed by coronary angiography (CAG) admitted to the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (“our hospital” for short) were selected as the observation group. A total of 63 healthy medical examiners admitted to our hospital at the same time served as the control group. According to the Gensini score, patients with coronary heart disease were divided into low-risk group (n = 23), intermediate-risk group (n = 22) and high-risk group (n = 22). The levels of Apo AI/Apo B, homocysteine, low density lipoprotein, cholesterol and triglyceride in each group were compared to explore the correlation between the severity of coronary artery disease and the indexes of Apo AI/Apo B, homocysteine and blood lipids. Results There were no significant differences in cholesterol and triglyceride levels between the low-risk group, the intermediate-risk group and the high-risk group (P > 0.05). The levels of cholesterol and triglyceride in the low-risk group, the intermediate-risk group and the high-risk group were higher than those in the control group, the differences were statistically significant (P < 0.05). The Apo AI/Apo B in the intermediate-risk group and the high-risk group were lower than the low-risk group, but the homocysteine and low-density lipoprotein levels were higher than the low-risk group, the differences were statistically significant (P < 0.05); Apo AI /Apo B in the high-risk group was lower than the intermediate-risk group, but homocysteine and low density lipoprotein levels were higher than the intermediate-risk group, the differences were statistically significant (P < 0.05). The levels of homocysteine and low density lipoprotein in the low-risk group, the intermediate-risk group and the high-risk group were higher than those in the control group, and the Apo AI/Apo B was lower than that in the control group, the differences were statistically significant (P < 0.05). Apo AI/Apo B was negatively correlated with coronary artery disease (r = -0.189, P < 0.05), and positively correlated with homocysteine and low-density lipoprotein coronary heart disease (r = 0.072-0.095, P < 0.05). Conclusion Apo AI/Apo B, homocysteine and low density lipoprotein levels are correlated with the severity of coronary artery disease, which can be used to predict and judge the disease.
李琳1 宋婷婷2▲. 冠心病冠脉病变程度与Apo AI/Apo B、同型半胱氨酸、血脂指标的相关性[J]. 中国医药导报, 2019, 16(17): 35-38.
LI Lin1 SONG Tingting2▲. Correlation between the degree of coronary artery disease and Apo AI/Apo B, homocysteine and blood lipids. 中国医药导报, 2019, 16(17): 35-38.
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2019, Vol. 16 
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