干细胞治疗闭合性不完全肌腱损伤的研究进展

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摘要随着体育事业和全民健身的发展，闭合性不完全肌腱损伤发病率逐年上升。目前，临床上常用的治疗方法如非甾体类抗炎药、针灸理疗和声光电刺激等都存在一定的局限性。近年来，基因工程和组织工程不断发展，为干细胞治疗闭合性不完全肌腱损伤打下良好基础。但纵观国内外文献，应用干细胞治疗运动员闭合性不完全肌腱损伤的专题研究较少，本文拟对相关研究做一总结，为后续研究和临床治疗提供参考。

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	胡静1 李章华2

关键词 ：间充质干细胞, 肌腱损伤, 生长因子, 基因治疗

Abstract：With the development of sports and national fitness, the incidence of closed incomplete tendon injuries has increased every year. At present, clinically commonly used treatment methods such as non-steroidal anti-inflammatory drugs, acupuncture physiotherapy and acoustic and optical stimulation have certain limitations. In recent years, genetic engineering and tissue engineering have been continuously developed, laying a good foundation for stem cell treatment of closed incomplete tendon injury. However, through the literatures at home and abroad, there are few special studies on the application of stem cell therapy for athletes with closed incomplete tendon injury. This paper intends to summarize the related research and provide reference for follow-up research and clinical treatment.

Key words： Mesenchymal stem cells Tendon injury Growth factor Gene therapy

基金资助:国家自然科学基金资助项目（81472103）；
武汉市卫生计生委医学科研项目（WX18M01）。

通讯作者: 李章华（1973.6-），男，医学博士，教授，硕士生导师；研究方向：股骨头坏死的机制。

作者简介: 胡静（1991.8-），男，武汉体育学院研究生院2017级运动医学专业在读硕士研究生；研究方向：运动医学。

引用本文:

胡静1 李章华2. 干细胞治疗闭合性不完全肌腱损伤的研究进展[J]. 中国医药导报, 2019, 16(25): 32-36,48.
HU Jing1 LI Zhanghua2. Research progress of stem cells in treatment of closed incomplete tendon injury. 中国医药导报, 2019, 16(25): 32-36,48.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2019/V16/I25/32

[1] Bell R，Gendron NR，Anderson M，et al. A potential new role for myofibroblasts in remoeling of sub-rupture fatigue tendon injuries by exercise [J]. Sci Rep，2018，8（1）：8933.
[2] Chen M，Guo W，Gao S，et al. Biomechanical stimulus based strategies for meniscus tissue engineering and regeneration [J]. Tissue Eng Part B Rev，2018，24（5）：392-402.
[3] 唐欢，李章华，许海甲.兔骨髓间充质干细胞Runx2基因特异siRNA的设计和沉默作用[J].中国骨质疏松杂志，2014，20（9）：1089-1097.
[4] Ju X，Xue D，Wang T，et al. Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats [J]. Cardiovasc Toxicol，2018，18（5）：471-481.
[5] Han W，Chen L，Liu J，et al. Enhanced tenogenic differentiation and tendon-like tissue formation by CHIP overexpression in tendon-derived stem cells [J]. Acta Biochim Biophys Sin （Shanghai），2017，49（4）：1-9.
[6] Chen X，Yin Z，Chen JL，et al. Scleraxis-overexpressed human embryonic stem cell-derived mesenchymal stem cells for tendon tissue engineering with knitted silk-collagen scaffold [J]. Tissue Engineering Part A，2014，20（11/12）：1583-1591.
[7] Lee HY，Kim IK，Yoon HK，et al. Inhibitory Effects of Resveratrol on Airway Remodeling by Transforming Growth Factor-β/Smad Signaling Pathway in Chronic Asthma Model [J]. Allergy Asthma Immunol Res，2017，9（1）：25-34.
[8] Mao WF，Wu YF，Yang QQ，et al. Modulation of digital flexor tendon healing by vascular endothelial growth factor gene transfection in a chicken model [J]. Gene Therapy，2017，24（4）：234-240.
[9] 陆文君，李昭铸.生长因子基因治疗与干细胞治疗在肌腱损伤愈合中的应用进展[J].中国运动医学杂志，2017， 37（2）：172-177.
[10] Gelberman RH，Linderman SW，Jayaram R，et al. Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon Healing [J]. Clin Orthop Relat Res，2017，475（9）：2318-2331.
[11] Shoaib A，Mishra V. Surgical repair of symptomatic chronic achilles tendon rupture using synthetic graft augmentation [J]. Foot Ankle Surg，2017，23（3）：179-182.
[12] Park YH，Kim TJ，Choi GW，et al. Achilles tendinosis does not always precede Achilles tendon rupture [J]. Knee Surg Sports Traumatol Arthrosc，2018. doi：10.1007/s00167-018-5172-3. [Epub ahead of print]
[13] 汪晶晶，马月辉，关伟军.脂肪干细胞促进肌腱损伤修复研究进展[J].生物技术进展，2018（1）：7-13.
[14] Morgan S，Coetzee FF. Proposing a Patellar Tendinopathy Screening tool following a systematic review [J]. S Afr J Physiother，2018，74（1）：454.
[15] Benca E，Willegger M，Wenzel F，et al. Biomechanical evaluation of two methods of fixation of a flexor hallucis longus tendon graft [J]. Bone Joint J，2018，100-B（9）：1175-1181.
[16] Xu SY，He YB，Deng SY，et al. Intensity-dependent effect of treadmill running on rat Achilles tendon [J]. Exp Ther Med，2018，15（6）：5377-5383.
[17] Snedeker JG，Foolen J. Tendon injury and repair- A perspective on the basic mechanisms of tendon disease and future clinical therapy [J]. Acta Biomater，2017，63：18-36.
[18] Yin Z，Guo J，Wu TY，et al. Stepwise Differentiation of Mesenchymal Stem Cells Augments Tendon-Like Tissue Formation and Defect Repair In Vivo[J]. Stem Cells Transl Med，2016，5（8）：1106-1116.
[19] 李於聪，倪明，柴伟，等.骨髓间充质干细胞构建组织工程化肌腱的实验[J].解放军医学院学报，2017，38（7）：639-643.
[20] Wang J，Zhang W，He GH，et al. Transfection with CXCR4 potentiates homing of mesenchymal stem cells in vitro and therapy of diabetic retinopathy in vivo [J]. Int J Ophthalmol，2018，11（5）：766-772.
[21] Wang LL，Yin XF，Chu XC，et al. Platelet-derived growth factor subunit B is required for tendon‐bone healing using bone marrow-derived mesenchymal stem cells after rotator cuff repair in rats [J]. J Cell Biochem，2018，119（11）：8897-8908.
[22] Reed SA，Leahy ER. Growth and Development Symposium：Stem cell therapy in equine tendon injury [J]. J Anim Sci，2013，91（1）：59-65.
[23] Bi YM，Ehirchion D，Kiltstm TM，et al. Identification of tendon stem/progenitor cells and the extracellular matrix in their niche [J]. Nature Medicine，2007，13（10）：1219-1227.
[24] Liu YP，Li SZ，Yuan F，et al. Infrapatellar fat pad may be with tendon repairing ability and closely ralated with the developing process of patella baja [J]. Medical Hypotheses，2011，74（4）：620-623.
[25] Zhang JY，Wang JH. Characterization of differential properties of rabbit tendon stem cells and tenocytes [J]. BMC Musculoskelet Disord，2010，11：10.
[26] Ni M，Liu PP，Rui Y，et al. Tendon-derived stem cells promote tendon repair in a rat patellar tendon windon defect mode [J]. J Orthop Res，2012，30（4）：613-619.
[27] Liu C，Luo JW，Liang T，et al. Matrix stiffness regulates the differentiation of tendon-derived stem cells through FAK-ERK1/2 activation [J]. Exp Cell Res，2018，373（1/2）：62-70.
[28] Tian X，Jiang H，Chen Y，et al. Baicalein Accelerates Tendon-Bone Healing via Activation of Wnt/beta-Catenin Signaling Pathway in Rats [J]. Biomed Res Int，2018，2018：3849760.
[29] Liu W，Yin L，Yan X，et al. Directing the Differentiation of Parthenogenetic Stem Cells into Tenocytes for Tissue-Engineered Tendon Regeneration [J]. Stem Cells Transl Med，2017，6（1）：196-208.
[30] Luo Q，Song Y，Song G，et al. Indirect co-culture with tenocytes promotes promotes proliferation and mRNA expression of tendon ligeament rrliated genes in rat bone marrow mesenchymal stem cells [J]. Cytotechnology，2009， 61（1/2）：1-10.
[31] Bavin EP，Smith O，Baird AE，et al. Equine Induced Pluripotent Stem Cells have a Reduced Tendon Differentiation Capacity Compared to Embryonic Stem Cells [J]. Front Vet Sci，2015，2：55.
[32] Filomeno P，Dayan V，Touri?觡o C. Stem cell research and clinical development in tendon repair [J]. Muscles Ligaments Tendons J，2012，2（3）：204-211.
[33] Tang JB，Zhou YL，Wu YF，et al. Gene therapy strategies to improve strength and qualityof flexor tendon healing [J]. Expert Opin Biol Ther，2016，16（3）：291-301.
[34] Yang QQ，Shao YX，Zhang LZ，et al. Therapeutic strategies for flexor tendon healing by nanoparticle-mediated co-delivery of bFGF and VEGFA genes [J]. Colloids Surf B Biointerfaces，2018（164）：164-176.
[35] Lu M，Guo S，Hong F，et al. Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2 [J]. Exp Cell Res，2018， 371（2）：342-352.
[36] Zhu JH，Liao YP，Li FS，et al. Wnt11 promotes BMP9-induced osteogenic differentiation through BMPs/Smads and p38 MAPK in mesenchymal stem cells [J]. J Cell Biochem，2018，119（11）：9462-9473.
[37] Zong XM，Wu S，Li F，et al. Transplantation of VEGF-mediated Bone Marrow Mesenchymal Stem Cells Promotes Functional Improvement in a Rat Acute Cerebral Infarction Model [J]. Brain Research，2017（1676）：9-18.
[38] Lu YF，Liu Y，Fu WM，et al. Long noncoding RNA H19 accelerates tenogenic differentiation and promotes tendon healing through targeting miR-29b-3p and activating TGF-beta1 signaling [J]. FASEB J，2017，31（3）：954-964.
[39] 史晓伟，周学兰.TGF-β1多效性与肌腱修复研究进展[J].中国运动医学杂志，2016，35（6）：588-593.
[40] Tuzmen C，Veroelis K，Weiss L，et al. Crosstalk between substance P and calcitonin gene-related peptide during heterotopic ossification in murine Achilles tendon [J]. J Orthop Res，2018，36（5）：1444-1455.
[41] 黄晓楠.BMP-14诱导骨髓间充质干细胞向肌腱细胞分化的实验研究[J].生物骨科材料与临床研究，2017， 14（2）：1-4.
[42] 黄弘轩，张姝江，白波.调控骨髓间充质干细胞成软骨分化的研究进展[J].中华关节外科杂志，2017，11（6）：655-661.
[43] Wang PZ，Zhang FJ，He QL，et al. Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1alpha in Chondrocytes and Promotes Articular Cartilage Repair [J]. PLoS One，2016，11（2）：e0148372.
[44] 史晓伟，张新定，龙碧波.IGF-1促进肌腱愈合研究进展[J].体育科技文献通报，2016，24（10）：17-18.
[45] Ayala-Cuellar AP，Kang JH，Jeung EB，et al. Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation [J]. Biomol Ther （Seoul），2018，27（1）：25-33.
[46] Lee SY，Kwon B，Lee K，et al. Therapeutic Mechanisms of Human Adipose-Derived Mesenchymal Stem Cells in a Rat Tendon Injury Model [J]. Am J Sports Med，2017， 45（6）：1429-1439.
[47] 孙传河，高鹏琳，廖伟龙.诱导多能干细胞应用研究进展[J].神经病学与神经康复学杂志，2017，8（2）：1-6.
[48] Guo H，Li B，Wang W，et al. Mesenchymal stem cells overexpressing IL-35：a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance [J]. Stem Cell Res Ther，2018，9（1）：254.