Relationship study between homocysteine, troponin T, high sensitivity C-reactive protein and cardiac function in patients with chronic heart failure
LU Xin1 DING Liping1 GAO Guojie1 ZHANG Zheng1 WANG Chengzhu1 ZHANG Lijuan1 JIN Zhitao1▲ ZHAO Guifeng2▲
1.Department of Cardiovascular Medicine, Rocket Army Characteristic Medical Center, Beijing 100088, China;
2.Department of Critical Care Medicine, Rocket Army Characteristic Medical Center, Beijing 100088, China
Abstract：Objective To investigate the relationship between homocysteine (Hcy), troponin T (TNT), high sensitive C-reactive protein (hs-CRP) and cardiac function in patients with chronic heart failure. Methods One hundred and fifteen patients with chronic heart failure admitted to the Department of Cardiology, Rocket Army General Hospital from January 2016 to January 2019 were selected as heart failure group. According to the New York Heart Association (NYHA) cardiac function classification standard, the heart failure group was divided into NYHA class Ⅱ group (26 cases), NYHA class Ⅲ group (35 cases) and NYHA class Ⅳ group (54 cases). Ninety-five healthy elderly people who had physical examination at the same time were selected as control group. The levels of Hcy, TNT, hs-CRP, NT-proBNP and left ventricular ejection fraction (LVEF) in each group were compared, and the correlation between Hcy, TNT, hs-CRP and NT-proBNP, LVEF were analyzed. Results The levels of TNT, hs-CRP, Hcy and NT proBNP in heart failure group were higher than those in control group, and LVEF was lower than that in control group (P < 0.01). The cardiac function was graded from grade Ⅱ to grade Ⅳ, the levels of serum TNT, hs-CRP, Hcy and NT-proBNP increased gradually, LVEF decreased gradually, the differences were statistically significant (P < 0.01). The levels of serum TNT, hs-CRP and Hcy were positively correlated with NT-proBNP (r = 0.75, 0.61, 0.69), and negatively correlated with LVEF (r = -0.71, -0.59, -0.64), and the differences were statistically significant (P < 0.05). Conclusion The levels of Hcy, TNT and hs-CRP in patients with heart failure are significantly increased, and the levels of Hcy, TNT and hs-CRP are positively correlated with NT-proBNP, and negatively correlated with LVEF. Therefore, they can be used as important indicators to evaluate the severity of heart failure.
卢鑫1 丁力平1 高国杰1 张铮1 王承竹1 张丽娟1 靳志涛1▲ 赵贵锋2▲. 慢性心力衰竭患者同型半胱氨酸、肌钙蛋白T、高敏C反应蛋白与心功能的相关性研究[J]. 中国医药导报, 2020, 17(26): 45-48.
LU Xin1 DING Liping1 GAO Guojie1 ZHANG Zheng1 WANG Chengzhu1 ZHANG Lijuan1 JIN Zhitao1▲ ZHAO Guifeng2▲. Relationship study between homocysteine, troponin T, high sensitivity C-reactive protein and cardiac function in patients with chronic heart failure. 中国医药导报, 2020, 17(26): 45-48.
[1] 都丽萍，李喜西，杜小莉，等.心力衰竭患者地高辛中毒的药物治疗管理[J].中国临床药理学杂志，2016，32（21）：2000-2002.
[2] 宋翠，郑刚.同型半胱氨酸及脑钠肽水平与慢性心力衰竭严度的相关性分析[J].中国心血管病研究，2018，16（4）：337-339.
[3] Cao WW，Chen JW，Chen YF，et al. Advanced glycation end products promote heart failure through inducing the immune maturation of dendritic cells [J]. Appl Biochem Biotechnol，2014，172（8）：4062-4077.
[4] 陶玲.心力衰竭患者血清CA125、BNP水平变化及临床意义[J].医药论坛杂志，2013，34（3）：3-5.
[5] Dunlay SM，Roger VL． Understanding the epidemic of heart failure：past，present，and future [J]． Curr Heart Fail Rep，2014，11（4）：404-415．
[6] Ponikowski P，Voors AA，Anker SD，et al. The task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology （ESC）Developed with the special contribution of the Heart Failure Association （HFA） of the ESC [J]. Eur Heart J，2016，37（27）：2129-2200.
[7] 李雷花，孙俊红.血清Hcy，CysC，NT-proBNP，D-dimmer联合检测在慢性心力衰竭诊断及预后评估中的价值[J].实验与检验医学，2018，36（3）：427-430，433.
[8] DeBerge M，Shah SJ，Wilsbacher L，et al. Macrophages in heart failure with reduced versus preserved ejection fraction [J]. Trends Mol Med，2019，25（4）：328-340.
[9] Peng Y，Ou BQ，Li HH，et al. Synergistic effect of atorvastation and folic acid on cardiac function and ventricular remodeling in Chronic heart failure patients with hyperhomocysteinemia [J]. Med Sci Monit，2018（24）：3744-3751.
[10] 施洋，李澜，邢晓雪，等.心肌纤维化与慢性充血性心力衰竭研究进展[J].中国临床药理学杂志，2016，32（1）：87-90．
[11] 刘晶，高敏.肌钙蛋白Ｔ与慢性心力衰竭的相关性及对急性心肌梗死的鉴别效果研究[J].中国现代药物应用，2017，11（10）：23.
[12] 邹甜甜，费安兴，高淑珍，等.心力衰竭伴肺部感染患者炎性因子，N端脑钠肽前体的水平变化及临床意义[J].河北医药，2018，21（3）：329-331.
[13] 王韶屏，廖玮，许振业，等.优化药物治疗慢性缺血性心力衰竭及ICD植入状况分析[J].实用医院临床杂志，2016，13（5）：81-83.
[14] Magnoni M，Masson S，Andreini D，et al. Usefulness of high-sensitivity cardiac troponin T for the identification of outlier patients with diffuse coronary atherosclerosis and low-risk factors [J]. Am J Cardiol，2016，117（9）：1397-1404.
[15] Pello AM，Cristóbal C，Tarín N，et al. Differential profile in inflammatory and miner M metabolism biomarkers in patients with ischemia heart disease without classical coronary risk factors [J]. J Cardiol，2015，66（1）：22-27.
[16] 王玲.肌钙蛋白心肌酶谱联合脑钠肤对急性心梗患者的诊断价值[J].中国实用医药杂志，2012，7（34）：19-21.
[17] Keshteli AH，Baracos VE，Madsen KL. Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflamnmtory bowel disease：a review [J]. World J Gastroenterol，2015，21（4）：1081.
[18] 郭艳梅.血浆D-二聚体、BNP、CysC、Hcy及hs-CRP联合检测在慢性心衰患者中的变化及临床价值[J].实验与检验医学，2018，36（4）：520-522.
[19] Fassett RG，Robertson IK，Ball MJ，et al. Effects of atorvastatin on biomarkers of inflammation in chronic kidney disease [J]. Clin Nephrol，2014，81（2）：75-85.
[20] Ma Y，Li L，Geng XB，et al. Correlation between hyperhomo-cysteinemia and outcomes of patients with acute myocardial infarction [J]. Am J Ther，2014，23（6）：1464-1468．
[21] 赵婷.慢性心力衰竭患者同型半胱氨酸水平与氨基末端 B型钠尿肽原相关性及其临床干预措施[J].中外医学研究，2018，16（17）：64-65.
[22] Haque A，Otsuji Y，Yoshifuku S，et al. Effects of valve dysfunction on doppler tei index [J]. J Am Soc Echocardiography，2012，15（9）：877-883.
[23] 任凯，冯津萍，陈树涛，等.慢性心力衰竭患者血液hs-cTnT、NT-proBNP、hs-CRP表达水平与心功能相关性研究[J].中国心血管病研究，2017，15（12）：1094-1097.
[24] 李建设.慢性心力衰竭病人血液BNP、cTnI及心肌酶谱水平变化与心功能的关系探讨[J].中西医结合心脑血管病杂志，2017，15（16）：2069-2071.
[25] Li B，Feng ZH，Sun L，et al. The blood genome-wideDNA methylation analysis reveals novel epigenetic changes in human heart failue [J]. Eur Rev Med Pharmacol Sci，2017，21（8）：1828-1836.
2020, Vol. 17 
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