Relationship between chemotherapy efficacy and neutrophil to lymphocyte ratio in advanced non-small cell lung cancer
CAO Yuhua1 LYU Yanru1 HAO Yanrong1 MO Xiaoyun2 FENG Guosheng1 HUANG Lu1 CHEN Xiaodan1 GAO Shan1 LU Shui1
1.Chemotherapy District One, Clinical Oncology Center, the People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region, Nanning 530021, China;
2.Department of Clinical Research, the People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region, Nanning 530021, China
Abstract：Objective To investigate the relationship between the neutrophil to lymphocyte ratio （NLR） and chemotherapy efficacy in advanced non-small cell lung cancer （NSCLC）. Methods A retrospective analysis of 80 NSCLC inpatients with inoperable stage ⅢB and Ⅳ who met the enrollment criteria in the People’s Hospital of Guangxi Zhuang Autonomous Region from January 2016 to January 2020. NLR was collected before treatment, and the relationship between NLR and chemotherapy efficacy was analyzed. According to the treatment effect, the patients were divided into the curative effect response group and the curative effect non-response group. Results Univariate analysis showed that there was a statistically significant difference in NLR between the two groups (P < 0.05). Multi-factor regression analysis showed that NLR was an independent risk factor affecting the effect of chemotherapy (OR > 1, P < 0.05). Conclusion The efficacy of chemotherapy is related to pre-treatment NLR, and the chemotherapy efficacy is better in patients with lower NLR. NLR may be an index to predict the efficacy of first-line chemotherapy in advanced NSCLC.
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2021, Vol. 18 
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