帕罗西汀联合奥氮平治疗抑郁症的meta分析

doi:10.20047/j.issn1673-7210.2022.26.31

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摘要目的系统评价帕罗西汀联合奥氮平治疗抑郁症的有效性与安全性。方法以“帕罗西汀”“奥氮平”“抑郁症”等检索词编写检索式，对VIP、The Cochrane Library、CNKI、Web of Science核心合集数据库、CBM、PubMed中的学术论文进行检索与筛选。通过RevMan 5.3软件对纳入文献进行偏倚风险评估及meta分析，检索时段为各数据库自建库至2022年5月。结果共纳入11篇随机对照试验，meta分析结果显示观察组汉密尔顿抑郁量表总分低于对照组（MD = -4.27，95%CI：-5.73～-2.80，P ＜ 0.000 01），其总有效率高于对照组（RR = 1.13，95%CI：1.03～1.24，P = 0.01）。两组不良反应总发生率比较，差异无统计学意义（RR = 0.77，95%CI：0.27～2.23，P = 0.63）。结论帕罗西汀联合奥氮平治疗抑郁症的效果显著，且安全性高，值得临床推广。

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关键词 ：帕罗西汀, 奥氮平, 抑郁症, 汉密尔顿抑郁量表, meta分析

Abstract：Objective To systematically evaluate the efficacy and safety of Paroxetine combined with Olanzapine in the treatment of depression. Methods The search formula was compiled with the search words “paroxetine”, “olanzapine”, and “depression”, the academic papers in the medical databases such as VIP, the Cochrane Library, CNKI, Web of Sciencecbm core collection database, PubMed, and Wanfang Data were searched and screened. The bias risk assessment and meta analysis of the included literature were carried out through the RevMan 5.3 software, the retrieval period is from the establishment of each database to May 2022. Results A total of 11 randomized controlled trials were included. The results of meta-analysis showed that the Hamilton depression scale of the observation group was lower than that of the control group (MD = -4.27, 95%CI:-5.73 to -2.80, P ＜ 0.000 01), and the total effective number was higher than that of the control group (RR = 1.13, 95%CI:1.03 to 1.24, P = 0.01). There was no significant difference in the total number of adverse reactions between the two groups (RR = 0.77, 95%CI: 0.27 to 2.23, P = 0.63). Conclusion Paroxetine combined with Olanzapine is effective and safe in the treatment of depression, which is worthy of clinical promotion.

Key words： Paroxetine Olanzapine Depression Hamilton depression scale Meta analysis

引用本文:

展西友. 帕罗西汀联合奥氮平治疗抑郁症的meta分析[J]. 中国医药导报, 2022, 19(26): 137-141.
ZHAN Xiyou. Meta analysis of Paroxetine combined with Olanzapine in the treatment of depression. 中国医药导报, 2022, 19(26): 137-141.

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https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2022.26.31 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I26/137

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