Analysis of the relationship between carcinoembryonic antigen level and radiotherapy effect in patients with locally advanced non-small cell lung cancer
ZONG Chunmei ZHAO Lin SUN Wei▲
Ward Three, Department of Oncology, Huaibei People’s Hospital, Anhui Province, Huaibei 235000, China
Abstract：Objective To study the relationship between the carcinoembryonic antigen (CEA) level and radiotherapy effect in patients with locally advanced non-small cell lung cancer (NSCLC). Methods A total of 89 patients with locally advanced NSCLC received radiotherapy in the Department of Oncology, Huaibei People’s Hospital, Anhui Province from January 2019 to December 2021 were selected and evaluated according to response evaluation criteria in solid tumor 1.1 one month after the end of radiotherapy. Patients with complete response and partial response were included in the radiotherapy sensitive group (41 cases). The rest were included in the radiotherapy resistance group (48 cases). The differences of serum CEA level before radiotherapy, and other clinical data between the two groups were analyzed. Logistic regression analysis and receiver operating characteristic (ROC) curve were used to evaluate the relationship between serum CEA level before radiotherapy and radiotherapy effect. Results The radiotherapy resistance rate of 89 patients was 53.93%. The age of diagnosis, the proportion of the maximum diameter of primary tumor ≥5.0 cm, the proportion of low differentiation, and the serum CEA level before radiotherapy in the radiotherapy resistance group were higher than those in the radiotherapy sensitive group, the differences were statistically significant (P＜0.05). Multivariate analysis showed that age of diagnosis, the proportion of low differentiation, and serum CEA level before radiotherapy were all factors influencing radiotherapy resistance in NSCLC patients (P＜0.05). ROC curve analysis showed that the area under the curve of serum CEA before radiotherapy in predicting radiotherapy resistance of NSCLC patients was 0.887 (P＜0.05). Conclusion Serum CEA level before radiotherapy is a influencing factor for radiotherapy resistance in patients with locally advanced NSCLC, and has a certain value in predicting radiotherapy effect.
纵春美 赵琳 孙伟▲. 局部晚期非小细胞肺癌患者癌胚抗原水平与放疗效果关系分析[J]. 中国医药导报, 2023, 20(8): 111-114.
ZONG Chunmei ZHAO Lin SUN Wei▲. Analysis of the relationship between carcinoembryonic antigen level and radiotherapy effect in patients with locally advanced non-small cell lung cancer. 中国医药导报, 2023, 20(8): 111-114.
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