Xp11.2易位/TFE3基因融合相关性肾癌的影像学表现

doi:10.20047/j.issn1673-7210.2023.13.35

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摘要目的探讨Xp11.2易位/TFE3基因融合相关性肾癌的影像特征表现。方法收集新疆维吾尔自治区人民医院2016年3月至2021年11月经病理学检查证实的15例Xp11.2易位/TFE3基因融合相关性肾癌患者的临床资料，分析肿瘤的CT、MRI资料，评估各项影像学特征。结果所有病灶均累及肾皮质和髓质，其中2例累及肾盂致肾积水；6例合并钙化，其中4例为环形或弧形钙化，2例为结节状或斑点状钙化；10例病灶内见坏死、囊变；6例见假包膜，其中2例包膜不完整；4例伴肾门及腹膜后淋巴结转移。4例T1加权成像呈等或、稍低信号，1例呈高信号；3例T2加权成像信号不均匀，呈等、稍高信号；弥散加权成像呈均匀或不均匀高信号；表观扩散系数图呈明显低信号。15例患者增强扫描后，6例皮质期明显强化，髓质期持续强化，延迟期明显廓清；9例皮质期、髓质期轻至中度强化，延迟期轻度廓清。结论 Xp11.2易位/TFE3基因融合相关性肾癌具有一定的CT及MRI特征，有助于提高该病的诊断率。

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	玉苏甫·肉孜　　艾合买提·托胡提　　张涛　　张旭　　陈杰

关键词 ：肾癌, Xp11.2易位, MRI, CT

Abstract：Objective To explore the imaging features of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions. Methods Clinical data of 15 renal cell carcinoma patients associated with XP11.2 translocation/TFE3 gene fusion confirmed by pathological examination in the People’s Hospital of Xinjiang Uygur Autonomous Region from March 2016 to November 2021 were collected. CT and MRI data of the tumor were analyzed and the imaging features were evaluated. Results All lesions involved the renal cortex and medulla, and two cases of hydronephrosis were caused by involvement of the renal pelvis; six cases were complicated with calcification, including four cases of annular or arc-shaped calcification and two cases of nodular or dotted calcification; necrosis and cystic change were observed in ten cases; pseudocapsule was seen in six cases, including incomplete capsule in two cases; lymph nodes metastasis were found in renal hilum and retroperitoneum in four cases. T1 weighted imaging showed equal or slightly low signal in four cases and high signal in one case; T2 weighted imaging signals of three cases were uneven, showing equal or slightly high signals; diffusion-weighted imaging presents uniform or non-uniform high signal; and the apparent diffusion coefficient diagram showed a significantly low signal. After enhanced scanning of the fifteen patients, six cases had significant enhancement in the cortical phase, sustained enhancement in the medulla phase and significant clearance in the delayed phase; nine cases had mild to moderate enhancement in the cortical and medulla phases, and slight clearance in the delayed phase. Conclusion Renal cell carcinoma associated with Xp11.2 translocation/ TFE3 gene fusions has certain CT and MRI characteristics, which is helpful to improve the diagnosis rate of this disease.

Key words： Renal cell carcinoma Xp11.2 translocation MRI CT

基金资助:[基金项目] 新疆维吾尔自治区自然科学基金资助项目（2018D01C137）。

通讯作者: 陈杰（1981.10-），男，副主任医师；研究方向：CT、MRI诊断

作者简介: 玉苏甫·肉孜（1989.6-），男，硕士；研究方向：CT、MRI诊断。

引用本文:

玉苏甫·肉孜　　艾合买提·托胡提　　张涛　　张旭　　陈杰. Xp11.2易位/TFE3基因融合相关性肾癌的影像学表现[J]. 中国医药导报, 2023, 20(13): 152-155.
Yusufu Rouzi Aihemaiti Tuohuti ZHANG Tao　ZHANG Xu　CHEN Jie. Imaging features of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions. 中国医药导报, 2023, 20(13): 152-155.

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https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2023.13.35 或 https://www.yiyaodaobao.com.cn/CN/Y2023/V20/I13/152

[1] 高凯波，叶慧义，王海屹，等.Xpll.2易位/TFE3基因融合相关性肾癌的MRl表现[J].海南医学，2017，28（7）：1120-1123.
[2] Lopez-Beltran A，Scarpelli M，Montironi R，et al. 2004 WHO cIassification of the renal tumors of the adults [J]. Eur Urol，2006，49（5）：798-805.
[3] 李浩杰，梁丽丽，李安琴，等.XP11.2异位/TFE3基因融合相关性肾癌MRI表现（5例报道并文献复习）[J].影像诊断与介入放射学，2016，25（5）：396-400.
[4] 高凯波，赵秀丽，叶慧义，等.Xpll.2易位/TFE3基因融合相关性肾癌的CT与MRI表现[J].中国医学影像学杂志，2017，25（3）：222-226，230.
[5] De Jong B，Molenaar IM，Leeuw JA，et al. Cytogenetics of a renal adenocarcinoma in a 2-year-old child [J]. Cancer Genet Cytogenet，1986，21（2）：165-169.
[6] Zhang W，Liu N，Guo H，et al. Gender difference analysis of Xp11.2 translocation renal cell carcinomas’s attack rate：a meta-analysis and systematix review [J]. BMC Urol，2020， 20：130.
[7] Calio A，Segala D，Munari E，et al. MiT family translocation renal cell carcinoma：from the early descriptions to the current knowledge [J]. Cancers（Basel），2019，11（8）：1110.
[8] 雷祎，刘芳，范承启，等.Xp11.2易位/TFE3基因融合相关性肾癌CT表现及病理对照分析[J].放射学实践，2017， 32（5）：504-508.
[9] 吴亚珊，阮立文，李巧新.MiT家族易位相关性肾细胞癌的研究进展[J].中华泌尿外科杂志，2021，42（12）：950- 953.
[10] 翟晶晶，肖渤瀚，孙琳，等.MiT家族易位性肾细胞癌的影像学表现及临床病理对照[J].实用放射学杂志，2021，37（7）：1131-1135.
[11] Dang TT，Ziv E，Weinstein S，et al. Computed tomography and magnetic resonance imaging of adult renal cell carcinoma associated with Xp11.2 translocation [J]. Comput Assist Tomogr，2012，36（6）：669-740.
[12] 钟燕，王海屹，陈鑫，等.Xp11.2易位/TFE3基因融合相关性肾癌的磁共振表现[J].中华医学杂志，2016，96（33）：2635-2639.
[13] 顿耀军，于路平，杜依青，等.Xp11.2 易位/TFE3基因融合相关性肾癌３例临床特征及文献回顾[J].现代泌尿外科杂志，2015，20（12）：863-866.
[14] 张雪，周胜利，苗重昌.Xp11.2易位/TFE3基因融合相关性肾癌的CT诊断及鉴别诊断[J].医学影像学杂志，2015，25（6）：1088-1090.
[15] 李小龙，史立新，杜其聪，等.Xp11.2易位/TFE3基因融合相关性肾癌的影像学征象分析[J].医学影像学杂志，2021，31（6）：1022-1025.
[16] Liu K，Xie P，Peng W，et al. Renal carcinomas associated with Xp11.2 translocation and TFE3 gene fusions：findings on MRI and computed tomography imaging [J]. J Magn Reson Imaging，2014，40（2）：440-447.
[17] Woo S，Kim SY，Lee MS，et al. MDCT Findings of renal cell carcinoma associated with Xp11.2 translocation and TFE3 gene fusion and papillary renal cell carcinoma [J]. AJR Am J Roentgenol，2015，204（3）：542-549.
[18] 刘于嘉，梁盼，高剑波.少见亚型肾癌CT表现及诊断价值[J].实用放射学杂志2019，35（2）：235-238.
[19] He J，Gan W，Liu S，et al. Dynamic computed tomographic features of adult renal cell carcinoma associated with with Xp11.2 translocation and TFE3 gene fusions：comparison with clear cell renal cell carcinoma [J].J Comput Assist Tomogr，2015，39（5）：730-736.
[20] Koo HJ，Choi HJ，Kim MH，et al. Radiologic-pathologic correlation of renal cell carcinoma associated with Xp11.2 translocation [J]. Acta Radiol，2013，54（7）：827-834.
[21] Muglia VF，Prando A. Renal cell carcinoma：histological classfication and correlation wite-imaging findings [J]. Radiol Bras，2015，48（3）：166-174.
[22] 陶磊，崔文静，刘丽，等.Xp11.2 易位/TFE3基因融合相关性肾癌影像表现及病理对照[J].临床放射学杂志，2016，35（8）：1190-1195.
[23] 张旭婷，任基伟，靳宏星，等.Xp11.2易位/TFE3基因融合相关性肾癌的影像诊断及鉴别诊断[J].医学影像学杂志，2019，29（6）：997-1001.
[24] Chen X，Zhu Q，Li B，et al. renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion：imaging findings in 21 patients [J]. Eur Radiol，2016，11（11）：e0166897.
[25] 吴军，龙黎，候四川.Xp11.2易位/TFE3基因融合相关性肾癌1例[J].医学影像学杂志，2018，28（5）：732.