Efficacy of probiotics in the treatment of Helicobacter pylori positive gastric ulcer and its effect on intestinal flora distribution and serum inflammatory factors
WANG Huixia ZHANG Caifeng ZHANG Chaoqun JI Juanjuan HAN Yu
Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical University, He’nan Province, Weihui 453100, China
Abstract：Objective To explore the effect of probiotics on the distribution of intestinal flora and serum inflammatory factors in patients with Helicobacter pylori (Hp) positive gastric ulcer. Methods A total of 170 patients with Hp positive gastric ulcer admitted to the First Affiliated Hospital of Xinxiang Medical College from May 2016 to October 2019 were selected and divided into observation group (85 cases) and control group (85 cases) according to the random number table method. The control group was given quadruple therapy, and the observation group was treated with Bifidobacterium and Lactobacillus triple live bacteria tablets on the basis of the control group. The clinical efficacy, Hp eradication rate, intestinal flora distribution, serum C-reactive protein (CRP), procalcitonin (PCT) and serum amyloid A (SAA) levels before and after treatment and the incidence of adverse reactions were compared between the two groups. Results The clinical effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). The eradication rate of Hp in the observation group was significantly higher than that in the control group (P ＜ 0.05). Four weeks after completion of treatment, the intestinal Bifidobacterium and Lactobacillus in the observation group were significantly higher than those in the control group (P ＜ 0.05). Four weeks after completion of treatment, the levels of serum CRP and SAA in the two groups were lower than those before treatment, and those in the observation group were significantly lower than those in the control group (P ＜ 0.05). There was no significant difference in the serum PCT of the two groups (P ＞ 0.05). There was no significant difference in incidence of adverse reaction between two groups (P ＞ 0.05). Conclusion Probiotics combined with quadruple therapy can improve the curative effect of Hp positive gastric ulcer patients, and its mechanism may be related to the regulation of intestinal flora and reduction of inflammatory reaction.
汪慧霞 张彩凤 张超群 姬娟娟 韩宇. 益生菌治疗幽门螺杆菌阳性胃溃疡的效果及对肠道菌群分布、血清炎症因子的影响[J]. 中国医药导报, 2021, 18(12): 154-158.
WANG Huixia ZHANG Caifeng ZHANG Chaoqun JI Juanjuan HAN Yu. Efficacy of probiotics in the treatment of Helicobacter pylori positive gastric ulcer and its effect on intestinal flora distribution and serum inflammatory factors. 中国医药导报, 2021, 18(12): 154-158.
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