Abstract：Objective To explore the expression level of human cartilage glycoprotein-39 in serum and urine of patients with renal tuberculosis and its diagnostic and prognostic value. Methods A total of 80 patients with renal tuberculosis admitted to the Department of Urology, the First Affiliated Hospital of Hebei North University (“our hospital” for short) from May 2019 to May 2020 were selected as the observation group, and 50 healthy people in our hospital were selected as the control group. Enzyme-linked immunosorbent assay was used to detect the concentration of human cartilage glycoprotein-39 in the serum and urine of the two groups, and the expression level of human cartilage glycoprotein-39 in serum and urine of renal tuberculosis patients and its diagnostic and prognostic value were explored. Results The levels of human cartilage glycoprotein-39 in urine and serum specimens of the observation group were significantly higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The expression level of human cartilage glycoprotein-39 in renal tuberculosis lesion tissue was significantly higher than that in normal tissues around the week, and the difference was statistically significant (P ＜ 0.05). The area under the ROC curve of human cartilage glycoprotein-39 was larger than that of PCR, and the difference was highly statistically significant (P ＜ 0.01). Conclusion The level of human cartilage glycoprotein-39 in the urine and serum of patients with renal tuberculosis is significantly higher than that of normal people. The preliminary diagnosis of renal tuberculosis can be made by understanding the level of human cartilage glycoprotein-39 in the patient’s body.
安海霞 李秀君 杨家鑫 陈怀安. 肾结核患者血清和尿液人软骨糖蛋白-39表达水平及其诊断和预后评估的价值[J]. 中国医药导报, 2021, 18(18): 80-83.
AN Haixia LI Xiujun YANG Jiaxin CHEN Huai’an. Expression of human cartilage glycoprotein-39 in serum and urine of patients with renal tuberculosis and its diagnostic and prognostic value. 中国医药导报, 2021, 18(18): 80-83.
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