上海地区抽动障碍患儿血清25-羟基维生素D的差异性分析

摘要
图/表
参考文献(29)
相关文章 (15)

全文: PDF (983 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨上海地区抽动障碍（TD）患儿血清25-羟基维生素D水平的差异。方法选择2018年5月至2020年5月上海市儿童医院（以下简称“我院”）神经内科门诊就诊的5～14岁TD患儿2001例，及我院同期体检健康的5～14岁正常儿童2670名。比较TD患儿与正常儿童血清25-羟基维生素D的差异，同时比较不同特征的TD患儿的血清25-羟基维生素D的差异。进一步将TD患儿按照每2岁（24个月）一个组段，划分为5个年龄组，包括5～6岁组（655例），7～8岁组（237例），9～10岁组（610例），11～12岁组（342例）和13～14岁组（157例），比较五组25-羟基维生素D的差异。结果 TD患儿血清25-羟基维生素D缺乏程度高于正常儿童，差异有统计学意义（P ＜ 0.05）。不同居住地、户外活动时间、核心家庭成员性格、饮食习惯、学习压力的TD患儿血清25-羟基维生素D缺乏程度比较，差异有统计学意义（P ＜ 0.05）。9～10岁组、11～12岁组及13～14岁组血清25-羟基维生素D缺乏程度高于5～6岁组和7～8岁组，差异有统计学意义（P ＜ 0.05）。结论上海地区TD患儿明显存在25-羟基维生素D缺乏，不同特征的TD患儿25-羟基维生素D缺乏程度不同，9岁以上的青少年缺乏最为显著。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	王四美1 张元凤1 袁芳1 陈学芬2 奚佳铭1 刘志萍1 陈育才1

关键词 ： 25-羟基维生素D, 抽动障碍, 儿童, 缺乏程度

Abstract：Objective To investigate the difference of serum 25- hydroxyvitamin D level in children with tic disorder (TD) in Shanghai. Methods From May 2018 to May 2020, 2001 children with TD aged 5 to 14 who visited the Department of Neurology of Shanghai Children’s Hospital (hereinafter referred to as “our hospital”) and 2670 normal children aged 5 to 14 who received physical examination in our hospital during the same period were selected. The serum 25-hydroxyvitamin D of children with TD was compared with that of normal children, and the serum 25-hydroxyvitamin D of children with TD with different characteristics was compared. Furthermore, children with TD were divided into five age groups according to one group every two years (24 months), including 5-6 years old group (655 cases), 7-8 years old group (237 cases), 9-10 old years group (610 cases), 11-12 years old group (342 cases), and 13-14 years old group (157 cases). The difference of 25- hydroxyvitamin D in the five groups was compared. Results The levels of serum 25-hydroxyvitamin D deficiency in children with TD was higher than those in normal children, the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in the levels of serum 25-hydroxyvitamin D deficiency among TD children with different residence, time of outdoor activities, personality of nuclear family members, eating habits, and study stress (P ＜ 0.05). The levels of serum 25-hydroxyvitamin D deficiency in 9-10 years old group, 11-12 years old group, and 13-14 years old group was higher than those in 5-6 years old group and 7-8 years old group, the differences were statistically significant (P ＜ 0.05). Conclusion There was a significant 25-hydroxyvitamin D deficiency in TD children in Shanghai, and the degree of 25-hydroxyvitamin D deficiency was different in TD children with different characteristics, and the deficiency was most significant in adolescents over nine years old.

Key words： 25-hydroxyvitamin D Tic disorder Children Level of deficiency

基金资助:上海市重中之重临床医学中心和重点学科建设项目（2017ZZ02019）。

通讯作者: 陈育才（1964.6-），博士，教授，主要从事小儿神经内科疾病的临床和基础研究工作。

引用本文:

王四美1 张元凤1 袁芳1 陈学芬2 奚佳铭1 刘志萍1 陈育才1. 上海地区抽动障碍患儿血清25-羟基维生素D的差异性分析[J]. 中国医药导报, 2022, 19(11): 57-60,72.
WANG Simei1 ZHANG Yuanfeng1 YUAN Fang1 CHEN Xuefen2 XI Jiaming1 LIU Zhiping1 CHEN Yucai1. Difference analysis of serum 25-hydroxyvitamin D levels in children with tic disorder in Shanghai#br#. 中国医药导报, 2022, 19(11): 57-60,72.

链接本文:

https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I11/57

[1] 侯成，杨召川，刘秀梅.血清维生素A、维生素D与抽动障碍症状严重程度、临床类型的相关性研究[J].中华行为医学与脑科学杂志，2020，4（29）：308-314.
[2] 陈先睿，黄建琪，陈玲.血清25羟维生素D水平在抽动障碍儿童中的临床研究[J].中国妇幼保健，2019，18（34）：4228-4231.
[3] Li HH，Shan L，Wang B，et al. Serum 25-hyroxyvitamin D levels and tic severity in Chinese children with tic disorders [J]. Psychiatry Res，2018，267：80-84.
[4] Bond M，Moll N，Rosello A，et al. Vitamin D levels in children and adolescents with chronic tic disorders：a multicentre study [J]. Eur Child Adolesc Psychiatry，2021.
[5] Ko■ovská E，Gaughran F，Krivoy A，et al. Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis，Schizophrenia，and Autism [J]. Front Psychiatry，2017，8：47.
[6] American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. fifth edition [M]. Arlington，VA：American Psychiatric Association，2013.
[7] Holick MF，Binkley NC，Bischoff-Ferrari HA，et al. Evaluation，treatment，and prevention of vitamin D deficiency：an Endocrine Society clinical practice guideline [J]. J Clin Endocrinol Metab，2011，96（7）：1911-1930.
[8] 中华预防医学会儿童保健分会.中国儿童维生素A、维生素D临床应用专家识[J].中国儿童保健杂志，2021，29（1）：110-116.
[9] 张欣，虞坚尔，吴敏.抽动障碍患儿及其不同辨证分型的年龄分布情况研究[J].上海中医药大学学报，2017，31（5）：48-50，65.
[10] 赵鑫，陈玉燕.120例儿童重度抽动障碍的临床特征分析[C]//浙江省心理卫生协会.浙江省心理卫生协会第十二届学术年会暨浙江省第三届心理咨询师大会学术论文集，2017：34-37.
[11] Jones KS，Saylam E，Ramphul K. Tourette Syndrome And Other Tic Disorders. In：StatPearls [M]. Treasure Island（FL）：StatPearls Publishing，2021.
[12] Efron D，Dale RC. Tics and Tourette syndrome [J]. J Paediatr Child Health，2018，54（10）：1148-1153.
[13] Hsu CJ，Wong LC，Lee WT. Immunological Dysfunction in Tourette Syndrome and Related Disorders [J]. Int J Mol Sci，2021，22（2）：853.
[14] Martino D，Johnson I，Leckman JF. What Does Immunology Have to Do With Normal Brain Development and the Pathophysiology Underlying Tourette Syndrome and Related Neuropsychiatric Disorders [J]. Front Neurol，2020， 11：567407.
[15] 贾润梅，图雅，王育民.抽动障碍中枢神经递质失衡发病机制的研究进展[J].中国医药科学，2020，10（21）：45-48.
[16] 卢青，孙丹，刘智胜.中国抽动障碍诊断和治疗专家共识解读[J].中华实用儿科临床杂志，2021，36（9）：647-652.
[17] Jurgiel J，Miyakoshi M，Dillon A，et al. Inhibitory control in children with tic disorder：aberrant fronto-parietal network activity and connectivity [J]. Brain Commun，2021，3（2）：fcab067.
[18] Cashman KD，Dowling KG，?譒krabáková Z，et al. Vitamin D deficiency in Europe：pandemic？[J]. Am J Clin Nutr，2016，103（4）：1033-1044.
[19] Groves NJ，Burne THJ. The impact of vitamin D deficiency on neurogenesis in the adult brain [J]. Neural Regen Res，2017，12（3）：393-394.
[20] Bouillon R，Carmeliet G，Lieben L，et al. Vitamin D and energy homeostasis：of mice and men [J]. Nat Rev Endocrinol，2014，10（2）：79-87.
[21] Amrein K，Scherkl M，Hoffmann M，et al. Vitamin D deficiency 2.0：an update on the current status worldwide [J]. Eur J Clin Nutr，2020，74（11）：1498-1513.
[22] 侯成，刘秀梅，杨晓燕，等.维生素D与儿童抽动障碍关系的研究进展[J].医学综述，2021，27（5）：857-861.
[23] Cui X，Pertile R，Liu P，et al. Vitamin D regulates tyrosine hydroxylase expression：N-cadherin a possible mediator [J]. Neuroscience，2015，304：90-100.
[24] 宁可，王金子，王欢，等.我国9地区儿童钙及维生素D补充情况及影响因素调查[J].中国妇幼保健，2014，29（32）：5289-5293.
[25] 郑双双，詹建英，朱冰泉，等.中国儿童维生素D营养状况流行病学研究进展[J].中华儿科杂志，2019，57（3）：232-234.
[26] Hu Y，Chen J，Wang R，et al. Vitamin D Nutritional status and its related factors for chinese children and adolescents in 2010-2012 [J]. Nutrients，2017，9（9）：E1024.
[27] 孙冠男，童彦瑞，徐力平，等.6～9岁儿童维生素D缺乏的危险因素分析[J].中国当代医药，2020，27（22）：173-177.
[28] Li HH，Xu ZD，Wang B，et al. Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders [J]. Neuropsychiatr Dis Treat，2019， 15：2443-2450.
[29] Libuda L，Naaresh R，Ludwig C，et al. A mendelian randomization study on causal effects of 25（OH） vitamin D levels on attention deficit/hyperactivity disorder [J]. Eur J Nutr，2021，60（5）：2581-2591.