Hematopoietic stem cell transplantation in severe aplastic anemia child patients with severe infection#br#
YUAN Meng QIN Maoquan WANG Bin ZHU Guanghua YANG Jun WU Runhui MA Jie LI Sidan
Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics (Capital Medical University) Key Laboratory of Major Diseases in Children, Ministry of Education Beijing Children’s Hospital, Capital Medical University National Center for Children’s Health, Beijing 100045, China
Abstract：Severe aplastic anemia and very severe aplastic anemia are critically ill, and the rate of implantation failure and transplant-related mortality will increase if the patients are associated with severe infection before transplantation. This article introduces the infection types, anti-infection programs, transplantation timing, pretreatment, graft-versus-host disease prevention programs and implantation situation of three children with severe infection before hematopoietic stem cell transplantation in Beijing Children’s Hospital, Capital Medical University. It can be seen from the prognosis of children that co-infection is not contraindicated for transplantation, anti-infection treatment should be actively carried out before transplantation, according to the guidelines of neutropenia with fever, the patient should be transplanted as soon as possible after infection control is stable, and salvage transplantation is feasible when it is difficult to control.
袁梦 秦茂权 王彬 朱光华 杨骏 吴润晖 马洁 李斯丹. 合并严重感染的重型再生障碍性贫血患儿造血干细胞移植[J]. 中国医药导报, 2022, 19(11): 95-98,102.
YUAN Meng QIN Maoquan WANG Bin ZHU Guanghua YANG Jun WU Runhui MA Jie LI Sidan. Hematopoietic stem cell transplantation in severe aplastic anemia child patients with severe infection#br#. 中国医药导报, 2022, 19(11): 95-98,102.
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