磷酸赖氨酸磷酸组氨酸无机焦磷酸盐磷酸酶在肿瘤中作用的研究进展

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摘要磷酸赖氨酸磷酸组氨酸无机焦磷酸盐磷酸酶（LHPP）是调控组氨酸去磷酸化的重要的酶，主要在肝、脑、肾组织中表达，其与组氨酸激酶共同调控组氨酸残基的磷酸化与去磷酸化，该酶的缺失可破坏组氨酸残基的磷酸化与去磷酸化的平衡，导致PI3K/Akt、Wnt/β-catenin等一系列信号通路的异常活化，进而引起细胞周期蛋白、凋亡蛋白的异常，促进肿瘤的发生发展。LHPP对于肿瘤患者的早期筛查、早期诊断和治疗及预后具有重要意义，并有望成为患者个体化治疗的新治疗靶点和预后指标。本综述在以往文献研究的基础上，对LHPP在肝癌、胶质瘤、肾癌等部分肿瘤中的作用的研究进展进行了总结，旨在为LHPP在肿瘤中未来的研究方向和应用提供参考。

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	汤翔1 王景芝2 刘娜1 陈德玉1

关键词 ：磷酸赖氨酸磷酸组氨酸无机焦磷酸盐磷酸酶, 肿瘤, 信号通路, 研究进展

Abstract：Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is one of the important enzyme regulating histidine dephosphorylation, mainly expressed in liver, brain and kidney, and the regulation of histidine residues together with histidine kinase phosphorylation and dephosphorylation. The deletion of LHPP can destroy the balance between phosphorylation and dephosphorylation of histidine residues, resulting in PI3K/Akt and Wnt/β-catenin which, leads to the abnormality of cyclin and apoptotic protein, and promotes the occurrence and development of tumor. LHPP is significant for early screening, early diagnosis, treatment and prognosis of tumor patients, and it is expected to become a new therapeutic target and prognostic index for individualized treatment of patients. Based on the previous literature research, this review summarizes the research progress of the role of LHPP in some tumors such as liver cancer, glioma, and kidney cancer, in order to provide reference for the future research direction and application of LHPP in tumors.

Key words： Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Tumor Signaling pathways Research progress

基金资助:国家自然科学基金面上项目（81572956）；
江苏省社会发展基金资助项目（BE2017696）；
江苏省医学创新团队项目（CXTDC2016009）。

通讯作者: 陈德玉（1962.6-），男，博士，博士生导师，教授，主任医师；研究方向：消化道肿瘤。

作者简介: 汤翔（1994.12-），男，江苏大学第一临床医学院2019级放射肿瘤学专业在读硕士研究生；研究方向：消化道肿瘤。

引用本文:

汤翔1 王景芝2 刘娜1 陈德玉1. 磷酸赖氨酸磷酸组氨酸无机焦磷酸盐磷酸酶在肿瘤中作用的研究进展[J]. 中国医药导报, 2022, 19(19): 34-40.
TANG Xiang1 WANG Jingzhi2 LIU Na1 CHEN Deyu1. Research progress of the role of phospholysine phosphohistidine inorganic pyrophosphate phosphatase in tumor. 中国医药导报, 2022, 19(19): 34-40.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I19/34

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