气体信号分子在非酒精性脂肪性肝病中的作用机制研究进展

doi:10.20047/j.issn1673-7210.2022.30.09

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摘要非酒精性脂肪性肝病（NAFLD）指除酒精因素，在肝细胞内脂肪异常沉积的一种代谢性肝损伤。气体信号分子一氧化氮、一氧化碳和硫化氢可通过调控VEGF-eNOS，PERK-eIF2-ATF4，Nrf2/HO-1，SESN2/AMPK/mTOR等信号轴改善NAFLD。本文主要将气体信号分子对NAFLD的调控作用及其分子机制进行综述，为今后利用气体信号分子及其供体治疗NAFLD提供新思路。

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	孔光耀蒋锋刘丽萍陈颖卿

关键词 ：气体信号分子, 一氧化氮, 一氧化碳, 硫化氢, 非酒精性脂肪性肝病

Abstract：Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver injury caused by abnormal deposition of fat in hepatocytes in addition to alcohol. Gasotransmitters, including nitric monoxide, carbon monoxide, and hydrogen sulfide can improve NAFLD by regulating VEGF-eNOS, PERK-eIF2-ATF4, Nrf2/HO-1,SESN2/AMPK/mTOR, and other signaling axes. This article mainly reviews the regulatory effects and molecular mechanisms of gasotransmitters on NAFLD, so as to provide new ideas for the treatment of NAFLD by gas signaling molecules and their donors in the future.

Key words： Gasotransmitters Nitrogen monoxide Carbon monoxide Hydrogen sulfid Non-alcoholic fatty liver disease

基金资助:国家自然科学基金面上项目（82000074）；
辽宁省教育厅科学研究经费项目（jyt-dldxjc202005）；
辽宁省大连市青年科技之星基金项目（2020RQ080）。

通讯作者: 陈颖卿（1986.12-），男，博士，副教授，硕士生导师，主要从事纤维化疾病机制及其药物筛选研究。刘丽萍（1974.2-）,女，博士，副教授，硕士生导师，主要从事心血管疾病靶向治疗及药物筛选研究。

作者简介: 孔光耀（1996.9-），男，大连大学医学院2019级临床检验诊断学在读硕士研究生，主要从事气体信号分子对纤维化疾病的作用及机制研究。

引用本文:

孔光耀蒋锋刘丽萍陈颖卿. 气体信号分子在非酒精性脂肪性肝病中的作用机制研究进展[J]. 中国医药导报, 2022, 19(30): 45-49.
KONG Guangyao JIANG Feng LIU Liping CHEN Yingqing. Research progress on the mechanism of gasotransmitters in non-alcoholic fatty liver disease. 中国医药导报, 2022, 19(30): 45-49.

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https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2022.30.09 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I30/45

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