Abstract:Objective To investigate the clinical value of dual-source CT dual-energy iodography imaging to assess the efficacy of radiotherapy for non-small cell lung cancer. Methods Seventy-nine patients with pathologically confirmed non-small cell lung cancer from October 2018 to October 2021 were collected from Shantou Central Hospital. All patients underwent dual-source CT dual-energy scans within a week before radiotherapy and at five weeks after radiotherapy. The results of five weeks review were divided into treatment-ineffective and treatment-effective groups according to the RECIST solid tumor criteria, and the change values of clinical target arteries (CTA), clinical target venous (CTV), normalized iodine concentration in the arterial phase (NICAP), normalized iodine concentration in the arterial venous phase (NICVP) of lesions before and after treatment were recorded in both groups. Results The number of patients enrolled was 47 in the treatment effective group and 32 in the treatment ineffective group. After treatment, CTA, CTV, NICAP, and NICVP in the effective group were lower than before treatment, and each indexs were lower than those in the ineffective group, and the differences were statistically significant (P < 0.05). The rate of change of NICAP, CTA, NICVP, and maximum diameter of lesion in the effective group were higher than those in the ineffective group, and the differences were statistically significant (P < 0.05). The rate of change of the maximum diameter of the lesion was positively correlated with the rate of change of CTA, NICAP, CTV, and NICVP (r > 0, P < 0.05). After radiotherapy, the ROC curve areas of CTA and NICAP change rates to assess the efficacy of NSCLC were 0.817 and 0.882, respectively. Conclusion Dual-energy CT iodography imaging can predict the therapeutic effect of radiotherapy for non-small cell lung cancer and provide a reference basis for precise clinical treatment.
汪丹凤 林黛英▲ 肖健宁 张晓琴 庄荞玮 胡泽桓. 双能量CT碘图在非小细胞肺癌放化疗效果评估中的应用价值[J]. 中国医药导报, 2022, 19(32): 22-25.
WANG Danfeng LIN Daiying▲ XIAO Jianning ZHANG Xiaoqin ZHUANG Qiaowei HU Zehuan. The value of dual-energy CT iodography in the assessment of radiotherapy efficacy in non-small cell lung cancer. 中国医药导报, 2022, 19(32): 22-25.