Clinical effect of Jiawei Jijiao Lihuang Decoction on patients with end-stage heart failure
ZHAO Dongsheng1 SUN Jing2
1.Department of Cardiology, Shuyang County Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangsu Province, Shuyang 223600, China; 2.Department of Cardiology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150030, China
Abstract:Objective To investigate the clinical effect of Jiawei Jijiao Lihuang Decoction on patients with end-stage heart failure, and the effects on left ventricular ejection fraction (LVEF) , N-terminal B-type natriuretic peptide (NT -proBNP), and hospitalization period. Methods A total of 62 patients with end-stage heart failure admitted to the Department of Cardiology, Shuyang County Hospital Affiliated to Nanjing University of Chinese Medicine from December 2018 to April 2021 were selected and they were divided into the traditional Chinese medicine group (31 cases) and the control group (31 cases) by random number table method. The control group was treated with the standard drug therapy recommended by the guideline, while the Chinese medicine group was treated with Jiawei Jijiao Lihuang Decoction on the basis of the standard drug therapy. The treatment period was seven days. Plasma NT-proBNP, LVEF, traditional Chinese medicine syndrome score, hospitalization period, liver and kidney function, electrolytes and blood routine were observed before and after treatment in both groups. Results After 7 days of treatment, the clinical efficacy of the traditional Chinese medicine group was better than that of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the scores of traditional Chinese medicine symptoms, NT-proBNP and LVEF between the two groups before treatment (P>0.05); after treatment, traditional Chinese medicine syndrome scores in both groups were lower than before treatment, and traditional Chinese medicine group was lower than control group (P<0.05). After treatment, NT-proBNP in both groups was lower than that before treatment, and the traditional Chinese medicine group was lower than that in control group (P<0.05). After treatment, LVEF in both groups was higher than that before treatment, and the traditional Chinese medicine group was higher than that in control group (P<0.05). The duration of hospitalization in traditional Chinese medicine group was shorter than that in control group (P<0.05). There was no significant difference in liver and kidney function electrolyte, blood routine and other safety indexes between two groups (P>0.05). Conclusion Jijiao Lihuang Decoction is effective in improving the clinical symptoms and signs of patients with end-stage heart failure, decreasing the level of NT-proBNP, increasing LVEF, and shortening the period of hospitalization. It has a definite curative effect and no obvious adverse reaction, it can use Jijiao Lihuang decoction for clinical reference.