Clinical effect of Liangxue Tuibi Decoction on patients of psoriasis vulgaris with syndrome of blood heat
GONG Ke1 GUO Jianhui1 GUO Wen1 DU Kaiqing1 SHEN Yana2
1.Department of Dermatology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei University of Chinese Medicine, Hebei Province, Cangzhou 061000, China;
2.Graduate School, Chengde Medical College, Hebei Province, Chengde 067000, China
Abstract：Objective To observe the clinical effect of Liangxue Tuibi Decoction on patients of psoriasis vulgaris with syndrome of blood heat. Methods A total of 80 patients of psoriasis vulgaris with syndrome of blood heat were treated in the Department of Dermatology, Cangzhou Hospital of Integrated traditional Chinese and Western Medicine Affiliated to Hebei University of Chinese Medicine from November 2020 to August 2021 were selected as the research object. They were divided into treatment group and control group by random number table method, 40 cases in each group. The control group was given Xiaoyin Granules, the observation group was given Liangxue Tuibi Decoction. After 8 weeks of treatment, the clinical effect was compared between the two groups, the changes in the psoriasis area and severity index (PASI) score, traditional Chinese medicine syndrome score, dermatology life quality index (DLQI) score, serum squmaous cell carcinoma antigen (SCCA) level and vascular endothelial growth factor (VEGF) level and the incidence of adverse reactions before and after treatment were observed. Results The clinical effect of the treatment group was better than that of the control group (P ＜ 0.05). After treatment, PASI scores in both groups were lower than those before treatment, and that in the treatment group was lower than that in the control group (P ＜ 0.05). After treatment, the traditional Chinese medicine syndrome scores of both groups were lower than those before treatment , and that in the treatment group was lower than that in the control group (P ＜ 0.05). After treatment, DLQI scores in both groups were lower than those before treatment, but there was no significant difference in DLQI scores between the two groups (P ＞ 0.05). After treatment, the levels of serum SCCA and VEGF in both groups were lower than those before treatment, and those in treatment group were lower than those in control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.2632, P = 0.6079). Conclusion Liangxue Tuibi Decoction can effectively improve the skin lesions and symptoms of psoriasis vulgaris patients with syndrome of blood heat, with obvious clinical effect and few adverse reactions, which is worthy of clinical application.
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