Prognostic value of serum copeptin combined with Marshall CT classification in infants with craniocerebral trauma
YU Xiongwu1 LI Shifu2 DING Zhiyong3 XIONG Liangjun1 LI Chuanfeng4 LI Caifen5 WANG Chaohong5 DONG Yun1
1.Department of Pediatric Surgery, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China;
2.General Office, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China;
3.Department of Medical Imaging, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China;
4.Department of Neonatology, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China;
5.Department of Anesthesiology, Qujing Maternal and Child Health Hospital, Yunnan Province, Qujing 655000, China
Abstract：Objective To explore the prognostic value of serum copeptin combined with Marshall CT classification in infants with craniocerebral trauma. Methods A total of 110 children with craniocerebral trauma treated in Qujing Maternal and Child Health Hospital from February 2018 to June 2020 were selected, they were divided into survival group and death group according to the living condition of 28 days in hospital. The level of serum copeptin were measured between two groups, and the degree of trauma was evaluated by Marshall CT grading. The factors affecting the prognosis of infant craniocerebral trauma and the value of copeptin combined with Marshall CT classification in predicting the prognosis of infant craniocerebral trauma were analyzed. Results There were statistically significant differences in injury type, blood loss, and Glasgow coma scale score between two groups (P < 0.05). The serum copeptin levels and Marshall CT scores of death group were higher than those of survival group, and the differences were statistically significant (P < 0.05). Copeptin and Marshall CT score were influential factors of infant death after traumatic brain injury (OR > 1, P < 0.05). The area under the curve predicted by copeptin combined with Marshall CT score was higher than that predicted by copeptin and Marshall CT score alone (P < 0.05). Conclusion Copeptin and Marshall CT classification have certain value in predicting the prognosis of infant craniocerebral trauma. The combination of two indexes can improve the prediction efficiency.
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