Abstract：Objective To investigate the deficiency status of vitamin A and vitamin D in children with recurrent upper respiratory tract infection and their relationship with immune function. Methods A total of 79 children with recurrent upper respiratory tract infection who were admitted to People’s Hospital of Chongqing Banan District from May 2019 to January 2022 were selected as the research group, and 75 healthy children who underwent physical examination during the same period were selected as the control group. Levels of vitamin A and vitamin D in both groups were detected by high performance liquid chromatography; the deficiency status of vitamin A and vitamin D in children with recurrent upper respiratory tract infection was counted; levels of vitamin A and Vitamin D in two groups were compared; immune functions (CD3+, CD4+, CD8+, CD4+/CD8+, immunoglobulin [Ig] A, IgG, and IgM) were compared between two groups; the correlation between vitamin A and vitamin D and immune function in children with recurrent upper respiratory tract infection were analyzed. Results Among the 79 children with recurrent upper respiratory tract infection, 55 cases (69.62%) of normal vitamin A, 12 cases (15.19%) of suspected subclinical deficiency, 7 cases (8.86%) of subclinical deficiency, and 5 cases (6.33%) of clinical deficiency; vitamin D was sufficient in 59 cases (74.68%), insufficient in 13 cases (16.46%), and deficient in 7 cases (8.86%). The levels of vitamin A and vitamin D in study group were lower than those in control group (P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG, and IgM in study group were lower than those in control group (P ＜ 0.05), while CD8+ in study group was higher than that in control group (P ＜ 0.05). The levels of vitamin A and vitamin D in children with recurrent upper respiratory tract infection were positively correlated with the levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG, and IgM (r ＞ 0, P < 0.05); while negatively correlated with CD8+ (r ＜ 0, P ＜ 0.05). Conclusion The deficiency status of vitamin A and vitamin D in children with recurrent upper respiratory tract infection still needs to be improved, and their vitamin A and vitamin D levels are closely related to immune function, which can assist in determining the deficiency status of vitamin A and vitamin D.
彭田川 喻梅▲. 反复上呼吸道感染患儿维生素A和维生素D缺乏现状及与免疫功能的关系研究[J]. 中国医药导报, 2022, 19(29): 97-100.
PENG Tianchuan YU Mei▲. Deficiency status of vitamin A and vitamin D in children with recurrent upper respiratory tract infection and their relationship with immune function. 中国医药导报, 2022, 19(29): 97-100.
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