Relationship between recurrent respiratory tract infection and serum 25-hydroxyvitamin D level, vitro allergens, and total IgE in infants
LIU Suqin1 LI Yan1▲ WANG Lei2 WEI Mengyue1
1.Department of Pediatrics, Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College, Jiangsu Province, Yangzhou 225002, China;
2.Department of Child Healthcare, Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College, Jiangsu Province, Yangzhou 225002, China
Abstract：Objective To explore the relationship between 25-(OH)D level, vitro allergens, and total immunoglobulin E (IgE) in recurrent respiratory tract infections(RRTI) in infants. Methods From December 2018 to June 2019, 100 infants with RRTI who admitted to Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College (hereinafter referred to as “our hospital”) were selected as observation group, another 100 infants with the first respiratory tract infection aged from 3 to 18 months in our hospital, who were followed up to two years old and still had only one history of respiratory tract infection as first infection group; 100 infants and toddlers who underwent physical examination in Department of Child Healthcare as healthy group. The first infection group and healthy group were included in control group. The 25-(OH)D levels were compared among all groups; vitro allergen indexes and total IgE were compared between observation group and control group; the risk factors of RRTI in infants were analyzed by logistic regression. Results The level of serum 25-(OH) D in observation group was lower than that in control group (P＜0.01). The level of serum 25-(OH) D in observation group was lower than that in healthy group and first infection group (P＜0.01). The positive rates of house dust, egg white, milk, and oak birch maple walnut sycamore poplar in observation group were higher than those in control group (P＜0.05 or P＜0.01). There was no significant difference in total IgE between two groups (P＞0.05). 25-(OH)D was a protective factor for RRTI (OR＜1, P＜0.05). Conclusion The serum 25-(OH)D level in RRTI children is low, and 25-(OH)D may play a protective role in the occurrence of RRTI. The positive rate of allergens in RRTI children is high, but the vitro allergen positive can not be used to predict whether the children are prone to RRTI.
刘素琴1 李燕1▲ 王磊2 魏梦月1. 婴幼儿反复呼吸道感染与血清25羟维生素D水平及体外过敏原、总IgE的关系[J]. 中国医药导报, 2022, 19(35): 88-91.
LIU Suqin1 LI Yan1▲ WANG Lei2 WEI Mengyue1. Relationship between recurrent respiratory tract infection and serum 25-hydroxyvitamin D level, vitro allergens, and total IgE in infants. 中国医药导报, 2022, 19(35): 88-91.
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