Mesh meta-analysis of multiple regimens for the treatment of ulcerative colitis with syndrome of intermingled heat and cold
LIU Shenfan1 GONG Yucheng2 KOU Mengjia2 WANG Zhibin2
1.The Second Clinical School of Medicine, Beijing University of Chinese Medicine, Beijing 100078, China;
2.Department of Spleen, Stomach, and Hepatobiliary, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Abstract：Objective To compare the efficacy of multiple regimens for ulcerative colitis (UC) with syndrome of intermingled heat and cold by mesh meta-analysis. Methods Randomized controlled trials (RCT) on intervention in the treatment of UC with syndrome of intermingled heat and cold were collected by searching CNKI, Wanfang Data, VIP, PubMed, Embase, and Web of Science. The clinical total effective rate of the included literatures was analyzed by Stata 15.0 and gemtc software package of R 3.6.1. Results A total of 33 RCTs were included, involving 2 263 patients. It includes eight schemes (scheme A [oral Chinese medicine], scheme B [oral Chinese medicine + Chinese medicine enema], scheme C [oral Chinese medicine + western medicine], scheme D [oral Chinese medicine + western medicine + Chinese medicine enema], scheme a [oral western medicine + western medicine enema], scheme b [oral western medicine + western medicine enema], scheme d [oral western medicine + Chinese medicine enema], and scheme e [Chinese medicine enema]). The results of mesh meta-analysis comparing the clinical total effective rate of eight schemes showed that scheme B was higher than scheme a [OR＝9.12, 95%CI: 2.38-42.82], scheme b [OR＝2.64, 95%CI: 1.11-6.61], scheme d [OR＝2.85, 95%CI: 1.20-7.03], and scheme e [OR＝10.32, 95%CI: 1.68-81.73], scheme A [OR＝2.46, 95%CI: 1.30-4.18], scheme C [OR＝4.80, 95%CI: 3.22-7.31], scheme D [OR＝3.71, 95%CI: 1.21-13.18] were higher than those of scheme a, and scheme C was higher than scheme A [OR＝0.52, 95%CI: 0.24-0.98], the differences were statistically significant (P＜0.05). The ranking probability of each scheme in descending order is as follows: scheme B＞scheme C＞scheme D＞scheme d＞scheme A＞scheme b＞scheme a＞scheme e. Conclusion The efficacy of Chinese medicine and the integration of traditional and western medicine in the treatment of UC with syndrome of intermingled heat and cold is better than that of western medicine, and oral Chinese medicine combined with Chinese medicine enema may be the best clinical treatment of UC with syndrome of intermingled heat and cold.
刘深梵1 宫宇澄2 寇梦佳2 王志斌2. 多种方案治疗寒热错杂型溃疡性结肠炎的网状meta分析[J]. 中国医药导报, 2022, 19(35): 110-114.
LIU Shenfan1 GONG Yucheng2 KOU Mengjia2 WANG Zhibin2. Mesh meta-analysis of multiple regimens for the treatment of ulcerative colitis with syndrome of intermingled heat and cold. 中国医药导报, 2022, 19(35): 110-114.
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