Abstract：Objective To investigate the relationship between homocysteine (Hcy), interleukin-6 (IL-6) and cognitive dysfunction after ischemic stroke. Methods A total of 150 patients with ischemic stroke who visited Shijiazhuang People’s Hospital from December 2018 to December 2020 were included in the study, according to the results of the Montreal cognitive assessment scale score, the patients were divided into cognitive impairment group of 110 cases and control group of 40 cases. The gender, age, heart rate, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, Hcy, and IL-6 levels were collected and compared between the two groups, the correlation between Hcy level, IL-6 level and Montreal cognitive assessment scale (MoCA) score were analyzed. Results The levels of Hcy and IL-6 in cognitive dysfunction group were higher than those in control group, and the differences were statistically significant (P＜0.05). Hcy and IL-6 level were the influencing factors of cognitive dysfunction in ischemic stroke patients (F=25.225, P＜0.001). Regression equation: MoCA score of patients with ischemic stroke =1.091-0.239×Hcy-0.503×IL-6, R2 of the model was 0.135, and the adjusted R2 was 0.130. Conclusion Hcy level and IL-6 level are the influencing factors of cognitive dysfunction in ischemic stroke patients.
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