Clinical effect of Self-made Shugan Jianzhong Decoction on the treatment of Helicobacter pylori positive chronic atrophic gastritis with syndrome of heat stagnation in liver and stomach
XIONG Li1 WANG Mei2 LUO Xilin3 YANG Yingjie3
1.Department of Internal Traditional Chinese Medicine, Nanchong Hospital of Traditional Chinese Medicine, Sichuan Province, Nanchong 637000, China; 2.Department of Traditional Chinese Medicine, People’s Hospital of Qingbaijiang District, Sichuan Province, Chengdu 610300, China;
3.Department of Preventive Medicine, Nanchong Hospital of Traditional Chinese Medicine, Sichuan Province, Nanchong 637000, China
Abstract：Objective To investigate the clinical effect of Self-made Shugan Jianzhong Decoction on the treatment of Helicobacter pylori (Hp) positive chronic atrophic gastritis (CAG) with syndrome of heat stagnation in liver and stomach. Methods A total of 112 patients with Hp positive CAG with syndrome of heat stagnation in liver and stomach admitted to Nanchong Hospital of Traditional Chinese Medicine of Sichuan Province from September 2020 to September 2022 were selected as the research objects. The patients were divided into control group and observation group by computer random drawing method, with 56 cases in each group. The control group was treated with quadruple therapy, and the observation group was additionally given Self-made Shugan Jianzhong Decoction internally. Both groups were treated with 14 days as a course of treatment for two courses. The clinical efficacy, one-time eradication rate of Hp were compared between the two groups, the traditional Chinese medicine symptom score and gastric function indexes were compared between the two groups before and after treatment, and the safety of treatment was observed. Results The clinical efficacy of the observation group was better than that of the control group, and the one-time eradication rate of Hp was higher than that of the control group (P＜0.05). After treatment, the scores of stomach fullness, abdominal pain and distention, acid regurgitation and belching, tongue red and liver-yellow, and the levels of pepsinogen Ⅰ, pepsinogen Ⅱ, gastrin-17 in both groups were lower than those before treatment, and those of the observation group were lower than those of the control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion In the treatment of Hp positive CAG with syndrome of heat stagnation in liver and stomach, Self-made Shugan Jianzhong Decoction can improve the symptoms of traditional Chinese medicine and stomach function of patients, and improve the effect and the rate of radical treatment of Hp, with good safety.
熊丽1 王玫2 罗熙林3 杨莹洁3. 自拟舒肝健中汤治疗肝胃郁热型幽门螺杆菌阳性慢性萎缩性胃炎的临床效果[J]. 中国医药导报, 2023, 20(19): 149-152,157.
XIONG Li1 WANG Mei2 LUO Xilin3 YANG Yingjie3. Clinical effect of Self-made Shugan Jianzhong Decoction on the treatment of Helicobacter pylori positive chronic atrophic gastritis with syndrome of heat stagnation in liver and stomach. 中国医药导报, 2023, 20(19): 149-152,157.
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