Research progress of local antimicrobial peptides preparation for chronic wound treatment
XIANG Yang1 JIANG Zhuang2 ZHI Xiaosong2 WANG Huasong2
1.Graduate School, Wuhan University of Science and Technology, Hubei Province, Wuhan 430065, China;
2.Department of Orthopedics, General Hospital of Central Theater Command of Chinese People’s Liberation Army, Hubei Province, Wuhan 430070, China
Abstract:Antimicrobial peptides (AMPs) have good antibacterial properties and promote wound healing, and are potential substitutes for traditional antibiotics. However, AMPs is sensitive to the external environment and has a short action time, which is limited in local applications. The novel local AMPs preparation formed by carrier delivery or change of dosage form can achieve the purpose of slow release of AMPs, enhance the stability of AMPs and optimize the biological efficiency, and show important advantages in the clinical application of chronic wounds. To date, a variety of AMPs preparation have been developed in the form of nanoparticles, hydrogels, nanoparticle supported hydrogels, and self-assembling peptides, etc. In this paper, the general situation, antibacterial activity, and wound healing promoting properties of AMPs, preparation type of local AMPs preparations currently developed, and efficacy influencing factors are reviewed. The future development prospect of AMPs is discussed.
[1] Wu YK,Cheng NC,Cheng CM. Biofilms in Chronic Wounds:Pathogenesis and Diagnosis [J]. Trends Biotechnol,2019,37(5):505-517.
[2] Chakraborty S,Chatterjee R,Chakravortty D. Evolving and assembling to pierce through:Evolutionary and structural aspects of antimicrobial peptides [J]. Comput Struct Biotechnol J,2022,20:2247-2258.
[3] Li X,Zuo S,Wang B. Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides [J]. Molecules,2022,27(9):2675.
[4] Zanna N,Tomasini C. Peptide-Based Physical Gels Endowed with Thixotropic Behaviour [J]. Gels,2017,3(4):39.
[5] Haidari H,Kopecki Z,Bright R,et al. Ultrasmall AgNP-Impregnated Biocompatible Hydrogel with Highly Effective Biofilm Elimination Properties [J]. ACS Appl Mater Interfaces,2020,12(37):41011-41025.
[6] Thapa RK,Diep DB,T?覬nnesen HH. Topical antimicrobial peptide formulations for wound healing:Current developments and future prospects [J]. Acta Biomater,2020,103:52-67.
[7] Wang J,Song J,Yang Z,et al. Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria [J]. J Med Chem,2019,62(5):2286-2304.
[8] Jin Y,Yang Y,Duan W. Synergistic and On-Demand Release of Ag-AMPs Loaded on Porous Silicon Nanocarriers for Antibacteria and Wound Healing [J]. ACS Appl Mater Interfaces,2021,13(14):16127-16141.
[9] Wali N,Shabbir A,Wajid N,et al. Synergistic efficacy of colistin and silver nanoparticles impregnated human amniotic membrane in a burn wound infected rat model [J]. Sci Rep,2022,12(1):6414.
[10] 刘嘉鑫,张广瑞,卢维新,等.壳聚糖季铵盐在生物材料中的应用[J].生物骨科材料与临床研究,2020,17(4):59-62.
[11] Maleki Dizaj S,Salatin S,Khezri K,et al. Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated Nanoparticles and Polymers [J]. Front Microbiol,2022,13:831655.
[12] Ge X,Cao Z,Chu L. The Antioxidant Effect of the Metal and Metal-Oxide Nanoparticles [J]. Antioxidants(Basel),2022,11(4):791.
[13] Ding X,Tang Q,Xu Z,et al. Challenges and innovations in treating chronic and acute wound infections:from basic science to clinical practice [J]. Burns Trauma,2022,10:tkac014.
[14] Galdopórpora JM,Morcillo MF,Ibar A,et al. Development of Silver Nanoparticles/Gelatin Thermoresponsive Nanoc omposites:Characterization and Antimicrobial Activity [J]. Curr Pharm Des,2019,25(38):4121-4129.
[15] 吴海能,耿康,王静,等.富血小板纤维蛋白联合姜黄素纳米颗粒水凝胶促糖尿病小鼠创面愈合[J].中国组织工程研究,2022,26(27):4300-4307.
[16] Arafa MG,El-Kased RF,Elmazar MM. Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents [J]. Sci Rep,2018,8(1):13674.
[17] 季梦婷,王新敬,边思梦,等.pH响应型药物缓释纳米载体制备及其性能[J].华北理工大学学报(自然科学版),2023,45(1):58-65.
[18] 黄鑫.乙酰肝素酶响应性多西他赛/骨化三醇纳米粒的研发[D].北京:中国科学院大学(中国科学院上海药物研究所),2021.
[19] Qiu L,Wang C,Lei X,et al. Gelatinase-responsive release of an antibacterial photodynamic peptide against Staphylococcus aureus [J]. Biomater Sci,2021,9(9):3433-3444.
[20] 廖小飞,赖余芬,凌连生,等.基于金纳米粒子的光学生物传感方法研究进展[J].分析测试学报,2021,40(6):816-821.
[21] Obuobi S,Tay HK,Tram NDT,et al. Facile and efficient encapsulation of antimicrobial peptides via crosslinked DNA nanostructures and their application in wound therapy [J]. J Control Release,2019,313:120-130.
[22] Monteiro C,Fernandes H,Oliveira D,et al. AMP-Chitosan Coating with Bactericidal Activity in the Presence of Human Plasma Proteins [J]. Molecules,2020,25(13):3046.
[23] Pranantyo D,Xu LQ,Kang ET,et al. Chitosan-Based Peptidopolysaccharides as Cationic Antimicrobial Agents and Antibacterial Coatings [J]. Biomacromolecules,2018,19(6): 2156-2165.
[24] 余炳田,赵枫,方钧,等.抗菌水凝胶涂层对踝关节骨折术后内植物相关感染的影响[J].生物骨科材料与临床研究,2021,18(5):64-68.
[25] Krishnaswamy VR,Mintz D,Sagi I. Matrix metalloproteinases:The sculptors of chronic cutaneous wounds [J]. Biochim Biophys Acta Mol Cell Res,2017,1864(11 Pt B):2220- 2227.
[26] Bryzek D,Golda A. Citrullination-Resistant LL-37 Is a Potent Antimicrobial Agent in the Inflammatory Environment High in Arginine Deiminase Activity [J]. Int J Mol Sci,2020,21(23):9126.
[27] Lai Z,Yuan X,Chen H,et al. Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability [J]. Biotechnol Adv,2022,59:107962.
[28] Malik E,Phoenix DA,Snape TJ,et al. Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum [J]. Mol Cell Biochem,2021,476(10): 3729-3744.
[29] Kuniyoshi TM,O’Connor PM,Lawton E,et al. An oxidation resistant pediocin PA-1 derivative and penocin A display effective anti-Listeria activity in a model human gut environment [J]. Gut Microbes,2022,14(1):2004071.
[30] Singh PK,Sharma S,Kumari A,et al. A non-pediocin low molecular weight antimicrobial peptide produced by Pediococcus pentosaceus strain IE-3 shows increased activity under reducing environment [J]. BMC Microbiol,2014,14:226.