Abstract：Objective To investigate the diagnostic value of electrophysiological visual evoked potential (VEP) detection combined with serum visceral adipose-specific serine protease inhibitor (Vaspin) expression in diabetic optic neuropathy (DON). Methods Clinical data of 259 patients (518 eyes) with type 2 diabetes mellitus admitted to Sir Run Run Hospital Nanjing Medical University from January 2020 to July 2022 were retrospectively analyzed, and they were divided into non-DON group (238 cases, 476 eyes) and DON group (21 cases, 42 eyes) according to whether they had DON or not. The factors affecting the occurrence of DON in diabetic mellitus patients were analyzed, and the diagnostic value of electrophysiological VEP detection and serum Vaspin expression for DON was analyzed. Results Duration of diabetes mellitus, P100 latent time in DON group were longer than those in non-DON group, serum Vaspin level was higher than that in non-DON group, and P100 amplitude was lower than that in non-DON group (P＜0.05). Duration of diabetes mellitus (OR=4.289), P100 latent time (OR=2.838), P100 amplitude (OR=0.328), and serum Vaspin (OR=3.466) were influencing factors for the occurrence of DON in diabetic mellitus patients (P＜0.05). The area under the curve of P100 latent time and P100 amplitude combined with serum Vaspin level in diagnosis of DON was higher than that in each single prediction (P＜0.05). Conclusion Electrophysiological VEP detection (P100 latent time, P100 amplitude) and serum Vaspin level have important value in the diagnosis of DON, and the combination of the three has higher diagnostic value.
2023, Vol. 20 
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