Diagnostic accuracy of breath test in detection of delayed gastric emptying: a meta-analysis
BAI Ying1 GAO Wei2 CONG Jialin2 CHENG Shuli2 ZHAO Xingjie3 ZHANG Li4 YANG Xiaohui5,6
1.College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
2.the Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100078, China;
3.Department of Gastroenterology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China;
4.Department of Endocrinology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China;
5.Department of Endocrinology, Dongzhimeng Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;
6.Traditional Chinese Medicine Master LYU Heren Work Station at Dongfang Hospital Affilated to Beijing University of Chinese Medicine, Beijing 100078, China
Abstract：Objective To evaluate the diagnostic value of breath test for delayed gastric emptying. Methods Database include PubMed, the Cochrane Library, China National Knowledge Internet, WanFang Data, VIP, CBM were searched to collect exsiting diagnostic accuracy tests on delayed gastric emptying diagnosed, the retrieval time was from database construction to April 2018. The fixed effect model was used for meta-analysis, and the research indicators included sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and the area under the curve (AUC). Results Ten studies with 434 objects were included. The sensitivity of breath test for diagnosis of delayed gastric emptying was 0.826 (95%CI: 0.728 to 0.894), and the specificity was 0.876 (95%CI: 0.800 to 0.925). The AUC was 0.92. The combined positive likelihood ratio was 6.640 (95%CI: 3.987 to 11.060), and the negative likelihood ratio was 0.198 (95%CI: 0.122 to 0.321). Conclusion Breath test is a useful tool for detecting delayed gastric emptying with a relatively high sensitivity and specificity. It is expected to be applied in clinic.
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2020, Vol. 17 
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