Research progress on the effects and mechanisms of epithelial growth factor receptor on tight junction
WANG Xue1,2 MENG Chen1,2 ZENG Wen1,2 WANG Yiming1,2 WANG Xianyu1,2 LI Qing1,2
1.Department of Anesthesiology, Affiliated Hospital of Hubei University of Medicine (Taihe Hospital of Shiyan City), Hubei Province, Shiyan 442000, China;
2.Institute of Anesthesiology, Department of Science and Technology, Hubei University of Medicine, Hubei Province, Shiyan 442000, China
Abstract：Tight junction is widely distributed in various organs and tumor tissues of the body, and plays an important role in the injury and repair of the barrier tissues, as well as in the development of the tumor tissues. Epithelial growth factor receptor (EGFR) is also expressed in these tissues, and its activation affects the state changes of tight junction of barrier and tumor tissues. However, the effects are significantly different: activation of the EGFR signaling pathway can enhance tight junction in barrier tissues and inhibit their destruction. Whereas, it reduces the tight junction between tumor cells and promotes the discrete cell metastasis. Therefore, studying these detailed effects and mechanisms of EGFR signaling pathway on tight junction may provide new therapeutic strategies on several barrier injury-associated diseases and tumors.
王雪1,2 蒙臣1,2 曾文1,2 王轶铭1,2 王贤裕1,2 李清1,2. 表皮生长因子受体信号通路影响紧密连接的作用与机制研究进展[J]. 中国医药导报, 2020, 17(15): 37-40.
WANG Xue1,2 MENG Chen1,2 ZENG Wen1,2 WANG Yiming1,2 WANG Xianyu1,2 LI Qing1,2. Research progress on the effects and mechanisms of epithelial growth factor receptor on tight junction. 中国医药导报, 2020, 17(15): 37-40.
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2020, Vol. 17 
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