Advances in molecular pathogenesis and treatment of prolactinoma
DUAN Jiafeng1 ZHANG Qiujuan2 HU Chunmei1 SHI Yang2 ZHANG Huaibi1
1.Department of Neurology, Shanghai Baoshan Integrated Hospital of Traditional Chinese and Western Medicine, Shanghai 201900, China;
2.Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Abstract：Prolactinoma is a type of tumor caused by imbalance of pituitary gland secretion. Excessive secretion of prolactin leads to prolactinoma or complications related to prolactin secretion. Studies have found that disturbances in cell signaling pathways such as phosphatidylinositol-3-kinase-protein kinase B, transforming growth factor-β could cause abnormal expansion of prolactin cells, excessive secretion of prolactin, and eventually lead to the formation of prolactinoma. The current clinical treatment for prolactinoma mainly uses dopamine agonists, but also surgical treatment and radiation therapy. With the study of the molecular mechanism of its pathogenesis, new targets have been provided for the treatment of tumors, such as programmed death-1, programmed death-ligand-1 and other immunosuppressive targets. This article reviews the molecular mechanism and the progress of treatment of prolactinoma in order to better guide the early diagnosis and clinical treatment of prolactinoma.
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2020, Vol. 17 
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