Relationship between serum hs-CRP, IL-15, and Hp infection in elderly patients with acute cholecystitis and its value in predicting Hp infection
CAI Liuyan JI Qianqian LI Hengjie
Emergency Intensive Care Center, Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical College, Zhejiang Province, Hangzhou 310000, China
Abstract：Objective To analyze the relationship between serum high-sensitivity C-reactive protein (hs-CRP), interleukin-15 (IL-15), and Helicobacter pylori (Hp) infection in elderly patietns with acute cholecystitis, and their value in predicting Hp infection. Methods The clinical data of 100 elderly patients with acute cholecystitis admitted to Zhejiang Provincial People’s Hospital from April 2017 to May 2019 were analyzed. According to Hp infection, they were divided into infected group and non-infected group. Serum hs-CRP and IL-15 levels were compared between two groups; the metaplasia of gallbladder mucosa and gastric epithelium was observed; the correlation of hs-CRP, IL-15, and Hp positive rate and the efficacy of hs-CRP and IL-15 in predicting Hp infection in elderly patients with acute cholecystitis were analyzed. Results Fifty-three elderly patients with acute cholecystitis were infected with Hp. Serum hs-CRP and IL-15 levels in infected group were higher than those in non-infected group (P < 0.05). The metaplasia rate of gallbladder mucosa and gastric epithelium in infected group was higher than that in non-infected group (P < 0.05). Hp positive rate was positively correlated with hs-CRP and IL-15 (r = 0.694, 0.677, P < 0.05); there was positive correlation between hs-CRP and IL-15 (r = 0.686, P < 0.05). When hs-CRP and IL-15 were combined to predict Hp infection in acute cholecystitis, the area under the curve was 0.870, the sensitivity and specificity were 75.47% and 95.74%, respectively. Conclusion Hp infection in elderly patients with acute cholecystitis can aggravate the local inflammatory response of cholecystitis, and induce release of hs-CRP and IL-15; hs-CRP and IL-15 are highly correlated with Hp infection, which can be used as a basis for preliminary screening of early Hp infection.
蔡柳燕 季茜茜 李恒杰. 老年急性胆囊炎患者血清hs-CRP、IL-15与Hp感染的关系及其预测Hp感染的价值[J]. 中国医药导报, 2022, 19(23): 9-12.
CAI Liuyan JI Qianqian LI Hengjie. Relationship between serum hs-CRP, IL-15, and Hp infection in elderly patients with acute cholecystitis and its value in predicting Hp infection. 中国医药导报, 2022, 19(23): 9-12.
[1] 郑伟，长孙卫国.血清总胆红素对急性胆囊炎、无征兆胆总管结石伴胆囊结石的预测价值研究[J].中国现代普通外科进展，2021，24（4）：282-285.
[2] Danciu M，Simion L，Poroch V，et al. The role of histological evaluation of Helicobacter pylori infection in obese patients referred to laparoscopic sleeve gastrectomy [J]. Rom J Morphol Embryol，2016，57（4）：1303-1311.
[3] Sánchez Cuén JA，Irineo Cabrales AB，León Sicairos NM，et al. Recurrence of infection and diversity of Helicobacter pylori strains in an adult population in Mexico treated with empirical standard triple therapy [J]. Rev Esp Enferm Dig，2017，110（11）：749-756.
[4] 熊茂程，雷艳梅，李良敏，等.结石性胆囊炎患者胆囊黏膜组织Hp DNA及CagA和CCK-AR表达研究[J].实用肝脏病杂志，2021，24（6）：923-926.
[5] 陈涛，金曜.急性胆囊炎术后医院感染病原菌及影响因素[J].中华医院感染学杂志，2020，30（14）：2184-2187.
[6] 刘梦婷.触珠蛋白（haptoglobin）促进胆囊癌细胞迁移、侵袭的分子机制研究[D].南京：南京师范大学，2020.
[7] 林继宗.《2016年世界急诊外科学会急性结石性胆囊炎指南》摘译[J].临床肝胆病杂志，2016，32（10）：1843-1846.
[8] 沙立娜，王慧娟，刘善珍，等.13C-尿素呼气试验在基层医院幽门螺杆菌检测中的应用[J].中华临床医师杂志（电子版），2019，13（1）：36-39
[9] 刘仕琪，吕毅.同源异型盒转录因子2与胆道系统肠化生及肿瘤的关系[J].中华肝胆外科杂志，2011，17（7）：596-598.
[10] 白济东，薛荣泉，白永乐，等.代谢综合征与胆囊结石的关系[J].临床肝胆病杂志，2020，36（3）：701-703.
[11] 郭之瑜，姚玉凤.上海市嘉定区江桥镇老年体检胆囊疾病流行特征及危险因素的相关分析[J].山西医药杂志，2020，49（16）：2095-2098.
[12] 张毅明，偰光华.老年急性胆囊炎发病特点及治疗效果[J].中国老年学杂志，2018，38（20）：4927-4929.
[13] Godara R，Kumar R，Yadav A，et al. Xanthogranulomatous cholecystitis masquerading as gallbladder cancer：case series and literature review [J]. Hell J Surg，2019， 91（2）：96-101.
[14] Allal S，Chrisment D，Blanc B. A cause of aerobilia without biliodigestive fistula：Acute cholecystitis with anaerobic gram-positive bacterial infection [J]. J Visc Surg，2016，153（5）：395-397.
[15] 杨天阔，唐小琼，申亚琳，等.幽门螺杆菌脂多糖结构及生物学功能研究进展[J].中华微生物学和免疫学杂志，2019，39（11）：880-884.
[16] 杨晓平，刘扬，吴明，等.炎症性肠病患者幽门螺杆菌感染分析[J].中华医院感染学杂志，2018，28（20）：3068-3071.
[17] Hamrah MH，Hamrah MS，Hassan Hamrah M，et al. Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients in Andkhoy Afghanistan [J]. Asian Pac J Cancer Prev，2017，18（11）：3123-3127.
[18] 胡南，段丽萍.固有免疫细胞在幽门螺杆菌相关性胃炎与胃癌发病中的作用[J].中华医学杂志，2019，99（28）：2237-2240.
[19] 张振山，姚天宇，许迪.幽门螺杆菌感染激活NF-κB信号通路促进胃癌SGC-7901细胞炎症因子释放[J].基因组学与应用生物学，2019，38（2）：971-976.
[20] 沈思源，刘欢，刘元元.慢性糜烂性胃炎合并幽门螺杆菌感染的临床及病理学分析[J].中国老年学杂志，2019， 39（7）：1603-1605.
[21] Fukuyama T，Futawatari N，Ichiki Y，et al. Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer [J]. In Vivo，2017，31（3）：403-407.
[22] 赵有英，詹雅珍.幽门螺杆菌根治术对合并幽门螺杆菌感染十二指肠溃疡患者胃窦炎症程度及炎症介质影响[J].世界华人消化杂志，2017，25（31）：2819-2824.
[23] Wu F，Hou XQ，Sun RR，et al. The predictive value of joint detection of serum amyloid protein A，PCT，and Hs-CRP in the diagnosis and efficacy of neonatal septicemia [J]. Eur Rev Med Pharmacol Sci，2019，23（13）：5904-5911.
[24] Okoye AA，DeGottardi MQ，Fukazawa Y，et al. Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques [J]. J Immunol，2019，203（11）：2928-2943.
[25] Kwon KW，Kim SJ，Kim H，et al. IL-15 Generates IFN-γ-producing Cells Reciprocally Expressing Lymphoid-Myeloid Markers during Dendritic Cell Differentiation [J]. Int J Biol Sci，2019，15（2）：464-480.
[26] 刘芸，滕贵根，王蔚虹，等.硫糖铝对幽门螺杆菌感染小鼠胃黏膜损伤的保护作用及其对胃肠菌群的影响[J].中华医学杂志，2019，99（20）：1546-1552.
[27] 李彦，马欢，李媛，等.NF-κB与IL-8在幽门螺杆菌相关性胃癌组织中的表达及意义[J].实用医学杂志，2016， 32（4）：583-585.
京公网安备 11010502046598号