Abstract：Objective To explore the relationship between perioperative period blood transfusion and postoperative survival and tumor-free survival after cholecystectomy. Methods The clinical data of 72 patients who underwent cholecystectomy in Jinhua People’s Hospital and Gansu Provincial People’s Hospital from June 2015 to June 2019 were retrospectively analyzed. The two groups of basic data were matched by propensity score matching. The general data, two-year overall survival rate, and tumor-free survival rate were compared between the two groups. Cox risk regression model was used to analyze the risk factors of postoperative survival and tumor-free survival. Results After propensity score matching, 60 cases of the 72 patients were successfully matched, 30 cases in the transfusion group and 30 cases in the non-transfusion group. There was no significant difference in general data between the two groups (P ＞ 0.05). The follow-up ended in June 2021, and the median survival time of the patients in the blood transfusion group and the non-transfusion group were 12 and 24 months, respectively. There was a statistically significant difference in the overall survival time between the two groups (P ＜ 0.05); there was a statistically significant difference in the tumor-free survival time between the two groups (P ＜ 0.05). Cox risk regression model analysis showed that after adjusting for TNM stage and liver invasion factors, perioperative blood transfusion increased the risk of death by 2.021 times and increased the risk of tumor recurrence by 1.762 times. Conclusion Perioperative blood transfusion reduces two-year overall survival and tumor-free survival in patients undergoing cholecystectomy.
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