Abstract：Objective To investigate the differences in serum levels of plasma glucose (PG), insulin (INS), and C-peptide (CP) in patients with type 2 diabetes mellitus (T2DM) after glucose load in Wuhan. Methods A total of 191 patients with T2DM admitted to Hubei Provincial Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from November 2020 to October 2021 were selected as the study group, and 74 non-diabetic patients admitted to our hospital during the same period were selected as the control group. After fasting for 8-10 h, 75 g glucose was orally administered within five minutes in both groups. The levels of PG, INS, and CP at fasting and 0.5, 1, 2, and 3 h after glucose load were collected and compared. According to the different progression of T2DM, patients in the study group were divided into T2DM uncomplicated group (144 cases) and T2DM with complications group (47 cases). At the same time, 21 patients diagnosed with prediabetes in the control group were selected as the prediabetes group. The differences of each detection index among the three groups were compared. In addition, according to the different complications of T2DM, the patients in T2DM with complications group were divided into peripheral neuropathy group (11 cases), retinopathy group (9 cases), ketoacidosis group (8 cases), macrovascular disease group (9 cases), and diabetic nephropathy group (10 cases). The differences of each detection index among the five groups were compared. Results Fasting PG, 0.5hPG, 1hPG, 2hPG, 3hPG in the study group were higher than those in the control group, and 0.5hINS, 1hINS, 2hINS, 0.5hCP, 1hCP, 2hCP were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Fasting PG, 0.5hPG, 1hPG, 2hPG, and 3hPG in T2DM uncomplicated group and T2DM with complications group were higher than those in prediabetes group; 0.5hINS, 1hINS, 0.5hCP, 1hCP, and 2hCP were lower than those in prediabetes group; 2hINS in T2DM with complications group were lower than those in prediabetes group, the differences were statistically significant (P ＜ 0.05). The 1hPG of retinopathy group was lower than that of ketoacidosis group, and the 1hCP and 2hCP of retinopathy group were lower than those of macrovascular disease group; the 2hPG of macrovascular disease group was lower than that of ketoacidosis group; fasting PG, 0.5hPG, 2hPG, and 3hPG in peripheral neuropathy group were higher than those in macrovascular disease group, and the differences were statistically significant (P ＜ 0.05). Conclusion The secretion of CP in T2DM patients after glucose load is different among different complications. In the early stage of diabetes, the secretion of INS and CP are delayed and the compensatory secretion is increased.
彭丽 唐婷 李玲 杨柳. 武汉地区2型糖尿病患者葡萄糖负荷后血糖、胰岛素及C肽水平差异性分析[J]. 中国医药导报, 2022, 19(30): 75-78,87.
PENG Li TANG Ting LI Ling YANG Liu. Analysis of differences of plasma glucose, insulin, and C-peptide levels in patients with type 2 diabetes mellitus after glucose load in Wuhan. 中国医药导报, 2022, 19(30): 75-78,87.
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