Research progress of refeeding syndrome in critical illnesses#br#
WANG Qingyuan1 XIE Tuxiu2 WEI Jei1 LYU Jingjun1
1.Department of Emergency, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China;
2.Department of General Practice, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430205, China
Abstract：Refeeding syndrome (RFS) is a potentially life-threatening condition caused by the body’s return to eating after prolonged starvation that encompasses a range of signature laboratory abnormalities (e.g., hypophosphatemia, hypokalemia, hypomagnesemia, and Thiamine deficiency) and / or clinical symptoms. It involves intricate metabolic and nutritional transformations and is common in critical illnesses. In recent years, RFS has made some progress in critical diseases such as anorexia nervosa (AN), sepsis, and malignant tumor. To prevent and treat RFS, long-term hunger, malnutrition, low body mass index, and other related risk factors should be screened as early as possible. An initial high-calorie (30-40 kcal/[kg·d]) refeeding regimen is recommended for high-risk patients with AN, and an initial low-calorie (10-20 kcal/[kg·d]) refeeding regimen is recommended for other critically high-risk patients. This paper mainly focuses on the risk factors of RFS in critical diseases and the research progress of RFS in common critical diseases, so as to improve the attention of clinicians.
[1] Mehanna HM，Moledina J，Travis J. Refeeding syndrome：what it is，and how to prevent and treat it [J]. BMJ，2008， 336（7659）：1495-1498.
[2] Ponzo V，Pellegrini M，Cioffi I，et al. The Refeeding Syndrome：a neglected but potentially serious condition for inpatients. A narrative review [J]. Intern Emerg Med，2021， 16（1）：49-60.
[3] Da SJ，Seres DS，Sabino K，et al. ASPEN Consensus Recommendations for Refeeding Syndrome [J]. Nutr Clin Pract，2020，35（2）：178-195.
[4] McKnight CL，Newberry C，Sarav M，et al. Refeeding Syndrome in the Critically Ill：a Literature Review and Clinician’s Guide [J]. Curr Gastroenterol Rep，2019，21（11）：58.
[5] Yoshida M，Izawa J，Wakatake H，et al. Mortality associated with new risk classification of developing refeeding syndrome in critically ill patients：A cohort study [J]. Clin Nutr，2021，40（3）：1207-1213.
[6] Reber E，Friedli N，Vasiloglou MF，et al. Management of Refeeding Syndrome in Medical Inpatients [J]. J Clin Med，2019，8（12）：2202.
[7] Ribeiro AC，Dock-Nascimento DB，Silva JJ，et al. Hypophosphatemia and risk of refeeding syndrome in critically ill patients before and after nutritional therapy [J]. Rev Assoc Med Bras（1992），2020，66（9）：1241-1246.
[8] Wang L，Xiao C，Chen L，et al. Impact of hypophosphatemia on outcome of patients in intensive care unit：a retrospective cohort study [J]. BMC Anesthesiol，2019，19（1）：86.
[9] 符加红，臧彬.重症监护病房患者低磷血症的发生及对预后的影响[J].中国危重病急救医学，2012，24（1）：29-32.
[10] Moskowitz L，Weiselberg E. Anorexia Nervosa/Atypical Anorexia Nervosa [J]. Curr Probl Pediatr Adolesc Health Care，2017，47（4）：70-84.
[11] Ornstein RM，Golden NH，Jacobson MS，et al. Hypophosphatemia during nutritional rehabilitation in anorexia nervosa：implications for refeeding and monitoring [J]. J Adolesc Health，2003，32（1）：83-88.
[12] Vduva N，Puskas L，Rchian AL，et al. Skeletal effects and refeeding syndrome in anorexia nervosa [J]. Balneo Research Journal，2020，11（4）：585-587.
[13] Puckett L，Grayeb D，Khatri V，et al. A Comprehensive Review of Complications and New Findings Associated with Anorexia Nervosa [J]. J Clin Med，2021，10（12）：2555.
[14] Rizzo SM，Douglas JW，Lawrence JC. Enteral Nutrition via Nasogastric Tube for Refeeding Patients With Anorexia Nervosa：A Systematic Review [J]. Nutr Clin Pract，2019， 34（3）：359-370.
[15] Koerner T，Haas V，Heese J，et al. Outcomes of an Accelerated Inpatient Refeeding Protocol in 103 Extremely Underweight Adults with Anorexia Nervosa at a Specialized Clinic in Prien，Germany [J]. J Clin Med，2020，9（5）：1535.
[16] Mira JC，Gentile LF，Mathias BJ，et al. Sepsis Pathophysiology，Chronic Critical Illness，and Persistent Inflammation-Immunosuppression and Catabolism Syndrome [J]. Crit Care Med，2017，45（2）：253-262.
[17] Costa NA，Gut AL，de Souza DM，et al. Serum thiamine concentration and oxidative stress as predictors of mortality in patients with septic shock [J]. J Crit Care，2014，29（2）：249-252.
[18] Al HS，Al-Dorzi HM，Al MA，et al. Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock [J]. BMC Pharmacol Toxicol，2021，22（1）：30.
[19] Miller CJ，Doepker BA，Springer AN，et al. Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock [J]. J Intensive Care Med，2020，35（5）：485-493.
[20] Padelli M，Aubron C，Huet O，et al. Is hypophosphataemia an independent predictor of mortality in critically ill patients with bloodstream infection？A multicenter retrospective cohort study [J]. Aust Crit Care，2021，34（1）：47-54.
[21] Marik PE，Khangoora V，Rivera R，et al. Hydrocortisone，Vitamin C，and Thiamine for the Treatment of Severe Sepsis and Septic Shock：A Retrospective Before-After Study [J]. Chest，2017，151（6）：1229-1238.
[22] Mitchell AB，Ryan TE，Gillion AR，et al. Vitamin C and Thiamine for Sepsis and Septic Shock [J]. Am J Med，2020，133（5）：635-638.
[23] Pressoir M，Desné S，Berchery D，et al. Prevalence，risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres [J]. Br J Cancer，2010，102（6）：966-971.
[24] Muthanandam S，Muthu J. Understanding Cachexia in Head and Neck Cancer [J]. Asia Pac J Oncol Nurs，2021，8（5）：527-538.
[25] Dolman RC，Conradie CM，Lombard MJ，et al. SASPEN Case Study：Nutritional management of a patient at high risk of developing refeeding syndrome [J]. South African Journal of Clinical Nutrition，2016，28（3）：140-145.
[26] Kaderbay A，Atallah I，Fontaine E，et al. Malnutrition and refeeding syndrome prevention in head and neck cancer patients：from theory to clinical application [J]. Eur Arch Otorhinolaryngol，2018，275（5）：1049-1058.
[27] Rasmussen SO，Kristensen MB，Wessel I，et al. Incidence and Risk Factors of Refeeding Syndrome in Head and Neck Cancer Patients-An Observational Study [J]. Nutr Cancer，2016，68（8）：1320-1329.
[28] Szeja N，Grosicki S. Refeeding syndrome in hematological cancer patients-current approach [J]. Expert Rev Hematol，2020，13（3）：201-212.
[29] Mgerian M，Havican S，Wolf F，et al. A Case of Hemodynamically Unstable Sick Sinus Syndrome Secondary to Refeeding Syndrome [J]. Cureus，2021，13（4）：e14625.
[30] Kodama M，Kazuma S，Tatsumi H，et al. Cardiac Failure Requiring Veno-Arterial Extracorporeal Membrane Oxygenation（VA-ECMO）Management in a Refeeding Syndrome Patient with Diabetic Ketoacidosis：A Case Report [J]. Am J Case Rep，2021，22：e930568.
[31] Lo GA，Rifici C，Caliri S，et al. Refeeding syndrome in a woman with pancreatitis：a case report [J]. J Int Med Res，2021，49（2）：1220786227.
[32] Cioffi I，Ponzo V，Pellegrini M，et al. The incidence of the refeeding syndrome. A systematic review and meta-analyses of literature [J]. Clin Nutr，2021，40（6）：3688-3701.
[33] Doig GS，Simpson F，Heighes PT，et al. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults：a randomised，parallel-group，multicentre，single-blind controlled trial [J]. Lancet Respir Med，2015，3（12）：943-952.
[34] Matthews-Rensch K，Capra S，Palmer M. Systematic Review of Energy Initiation Rates and Refeeding Syndrome Outcomes [J]. Nutr Clin Pract，2021，36（1）：153-168.
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