Relationship between visfatin, NF-κB and platelet activation parameters in unstable angina patients
SUN Xin1 WU Yanqiang2
1.The Second Department of Cardiology, the Second Hospital of Handan, Hebei Province, Handan 056001, China;
2.the Forth Department of Cardiololgy, Handan Central Hospital, Hebei Province, Handan 056001, China
Abstract:Objective To investigate the relationship between platelet activation parameters of serum Visfatin, nuclear factor-κB (NF- κB) and unstable angina pectoris (UA). Methods From April 2017 to September 2018, in the Second Hospital of Handan, 108 UA patients were selected as angina group, at the same time, 108 healthy patients underwent physical examination were selected as the health group. In the two groups, blood samples were collected on the day of admission to detect serum Visfatin, NF-κB and platelet granule membrane protein (CD63), platelet membrane glycoproteinⅡb-Ⅲa (PAC-1), platelet alpha particle surface membrane glycoprotein (CD62P). Serum Visfatin, NF-κB and platelet activation parameters of low, middle and high risk patients were compared. The correlation between serum Visfatin and NF-κB and platelet activation parameters in UA patients was observed by Pearson linear correlation analysis. Results The levels of serum Visfatin, NF-κB and CD63, PAC-1 and CD62P in angina pectoris group were higher than those in healthy group, the differences were statistically significant (P < 0.01). Serum levels of Visfatin, NF-κB and CD63, PAC-1 and CD62P in the low risk group were lower than those in the middle risk group and high-risk group, and these in the middle risk group were lower than the high risk group, the differences were statistically significant (P < 0.05). Pearson linear correlation analysis showed that serum visfatin and NF-κB were positively correlated with CD63 and PAC-1 (r = 0.671, 0.591, 0.507, 0.460, P < 0.05). There was no significant correlation between the two and CD62P (P > 0.05). Conclusion Visfatin and NF-κB were correlated with platelet activation parameters CD63 and PAC-1 in patients with UA. Visfatin, NF-κB and platelet activation parameters can be used as an important indicator for evaluating the condition of UA patients.
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