Abstract：Objective To observe the clinical significance of the ratio of plasma apolipoprotein B to apolipoprotein A1 (ApoB/ApoA1) in non-diabetic acute ischemic stroke. Methods A total of 78 cases of non-diabetic acute ischemic stroke patients hospitalized in Wuxi Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from July 2017 to July 2019 were selected as the stroke group, and 55 healthy subjects with physical examination results in our hospital during the same period were selected as the control group. The ratio of ApoB/ApoA1 in the two groups was compared, and the risk factors of non-diabetic acute ischemic stroke were analyzed by logistic regression, and the receiver operating characteristic (ROC) curve of the value of ApoB/ApoA1 in the diagnosis of non-diabetic acute ischemic stroke was drawn. Results The ApoA1 level in the stroke group was lower than that in the control group, and the ApoB/ApoA1 ratio in the stroke group was higher than that in the control group, with statistical significance (all P ＜ 0.05). Multivariate logistic regression analysis showed that the increase of ApoB/ApoA1 ratio and the decrease of ApoA1 level were independent risk factors for non-diabetic acute ischemic stroke (P ＜ 0.05). ROC curve analysis showed that the area under the curve of ApoB/ApoA1 ratio in the diagnosis of non-diabetic acute ischemic stroke was 0.876, 95%CI: 0.714-0.922, the sensitivity was 69.1%, the specificity was 95.2% and the best cutoff value was 0.853. Conclusion The increase of ApoB/ApoA1 ratio is a risk factor for patients with non-diabetic acute ischemic stroke. When the ratio of ApoB/ApoA1 in peripheral blood is higher than 0.853, the risk of non-diabetic acute ischemic stroke is greatly increased.
易晓净 李乐军. 非糖尿病急性缺血性脑卒中患者血浆ApoB/ApoA1比值的检测及其临床意义[J]. 中国医药导报, 2021, 18(19): 98-101.
YI Xiaojing LI Lejun. Detection and clinical significance of plasma ApoB/ApoA1 ratio in non-diabetic patients with acute ischemic stroke. 中国医药导报, 2021, 18(19): 98-101.
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