Effect and cost-effectiveness of autologous platelet-rich gel combined with negative pressure drainage on refractory diabetic foot in different treatment cycles
WANG Zhi1 GAO Chong2 LIU Xiaodong3 XU Tongdao1▲
1.Department of Endocrinology, the Second People’s Hospital of Lianyungang, Jiangsu Province, Lianyungang 222000, China; 2.Department of Orthopedics, the Second People’s Hospital of Lianyungang, Jiangsu Province, Lianyungang 222000, China; 3.Department of Nephrology, the Second People’s Hospital of Lianyungang, Jiangsu Province, Lianyungang 222000, China
Abstract:Objective To explore the effect and cost-effectiveness of autologous platelet-rich gel combined with negative pressure drainage on refractory diabetic foot in different treatment cycles. Methods A total of 85 patients with refractory diabetic foot admitted to the Second People’s Hospital of Lianyungang, Jiangsu Province from April 2019 to April 2022 were selected and divided into control group (43 cases, autologous platelet-rich gel combined with negative pressure drainage once a week) and observation group (42 cases, autologous platelet-rich gel combined with negative pressure drainage once every two weeks) by random number table method. Wound healing time, hospital stay, and clinical efficacy of the two groups were analyzed, serum inflammatory factors and antithrombine (AT) levels were analyzed before and after treatment, adverse reactions during treatment were recorded, and cost-effectiveness ratio was calculated. Results There were no significant differences in wound healing time, hospital stay, clinical efficacy, and total incidence of adverse reactions between the two groups (P>0.05). After four weeks of treatment, the levels of interleukin-6 and tumor necrosis factor-α in both groups were lower than before treatment, and the levels of AT were higher than those before treatment (P<0.05). After four weeks of treatment, there was no significant difference in the levels of interleukin-6, tumor necrosis factor-α, and AT between the two groups (P>0.05). The cost-effectiveness ratio of observation group was lower than that of control group. Conclusion Biweekly autologous platelet-rich gel combined with negative pressure drainage in patients with refractory diabetic foot doesn’t reduce clinical efficacy, but reduces cost-effectiveness ratio.
王智1 高冲2 刘晓东3 徐同道1▲. 不同治疗周期自体富血小板凝胶联合负压引流对难愈性糖尿病足的效果及成本-效益的影响[J]. 中国医药导报, 2023, 20(29): 121-124.
WANG Zhi1 GAO Chong2 LIU Xiaodong3 XU Tongdao1▲. Effect and cost-effectiveness of autologous platelet-rich gel combined with negative pressure drainage on refractory diabetic foot in different treatment cycles. 中国医药导报, 2023, 20(29): 121-124.